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Fbxl17 F-box and leucine-rich repeat protein 17 [ Mus musculus (house mouse) ]

Gene ID: 50758, updated on 8-Dec-2022

Summary

Official Symbol
Fbxl17provided by MGI
Official Full Name
F-box and leucine-rich repeat protein 17provided by MGI
Primary source
MGI:MGI:1354704
See related
Ensembl:ENSMUSG00000023965 AllianceGenome:MGI:1354704
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fbx13; Fbxo13; 6330576B01Rik; C130023C01Rik
Summary
Predicted to be involved in several processes, including G2/M transition of mitotic cell cycle; entrainment of circadian clock by photoperiod; and proteolysis involved in cellular protein catabolic process. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytosol and nucleus. Is expressed in inferior colliculus; midbrain ventricular layer; and ventral grey horn. Orthologous to human FBXL17 (F-box and leucine rich repeat protein 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 2.9), cortex adult (RPKM 2.8) and 28 other tissues See more
Orthologs
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Genomic context

See Fbxl17 in Genome Data Viewer
Location:
17; 17 E1.1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (63352944..63811179, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (63045949..63504184, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ephrin A5 Neighboring gene VISTA enhancer mm1538 Neighboring gene predicted gene, 34179 Neighboring gene predicted gene, 34324 Neighboring gene predicted gene, 53980 Neighboring gene predicted gene, 24730 Neighboring gene RIKEN cDNA 4930405O22 gene Neighboring gene predicted gene, 41607 Neighboring gene predicted gene 17228 Neighboring gene predicted gene, 18418 Neighboring gene peptidylprolyl isomerase A pseudogene 17_1026.1 Neighboring gene mitochondrial pyruvate carrier 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
F-box/LRR-repeat protein 17
Names
F-box only protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015794.1NP_056609.1  F-box/LRR-repeat protein 17

    See identical proteins and their annotated locations for NP_056609.1

    Status: VALIDATED

    Source sequence(s)
    AC154192, AF176529, BX515367, CJ179644, CT025670
    Consensus CDS
    CCDS50162.1
    UniProtKB/Swiss-Prot
    Q8BTC3, Q9QZN1
    Related
    ENSMUSP00000024761.7, ENSMUST00000024761.13
    Conserved Domains (3) summary
    cd09293
    Location:411573
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:362387
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:321368
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    63352944..63811179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160679.1XP_036016572.1  F-box/LRR-repeat protein 17 isoform X1

    Conserved Domains (3) summary
    cd09293
    Location:411573
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:362387
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:321366
    F-box-like
  2. XM_006524600.4XP_006524663.1  F-box/LRR-repeat protein 17 isoform X2

    Conserved Domains (3) summary
    cd09293
    Location:363456
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:362387
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:321366
    F-box-like

RNA

  1. XR_385343.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177143.2: Suppressed sequence

    Description
    NM_177143.2: This RefSeq was permanently suppressed because it contains the wrong CDS.