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Fbxw14 F-box and WD-40 domain protein 14 [ Mus musculus (house mouse) ]

Gene ID: 50757, updated on 26-Sep-2022

Summary

Official Symbol
Fbxw14provided by MGI
Official Full Name
F-box and WD-40 domain protein 14provided by MGI
Primary source
MGI:MGI:1354703
See related
Ensembl:ENSMUSG00000105589 AllianceGenome:MGI:1354703
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fbx12; Fbxo12; E330009N23Rik
Summary
Orthologous to human FBXW12 (F-box and WD repeat domain containing 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward ovary adult (RPKM 1.2) See more
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Genomic context

See Fbxw14 in Genome Data Viewer
Location:
9; 9 F2
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (109099857..109116797, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (109270789..109287729, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene F-box and WD-40 domain protein 13 Neighboring gene F-box and WD-40 domain protein 20 Neighboring gene predicted gene, 22821 Neighboring gene F-box and WD-40 domain protein 28

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC117492

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
F-box and WD-40 domain protein 14
Names
F-box only protein 12
F-box protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311159.1NP_001298088.1  F-box and WD-40 domain protein 14 isoform 2

    See identical proteins and their annotated locations for NP_001298088.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC122308, AK087709, AK166611, CT025696
    Consensus CDS
    CCDS81079.1
    UniProtKB/TrEMBL
    Q4FZL9, Q8C2Y5
    Related
    ENSMUSP00000107672.5, ENSMUST00000112041.6
    Conserved Domains (1) summary
    pfam12937
    Location:448
    F-box-like; F-box-like
  2. NM_015793.2NP_056608.1  F-box and WD-40 domain protein 14 isoform 1

    See identical proteins and their annotated locations for NP_056608.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC122308, CT025696
    Consensus CDS
    CCDS23550.1
    UniProtKB/TrEMBL
    Q8C2Y5
    Related
    ENSMUSP00000143404.2, ENSMUST00000198844.5
    Conserved Domains (2) summary
    COG2319
    Location:99316
    WD40; WD40 repeat [General function prediction only]
    pfam12937
    Location:448
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    109099857..109116797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512182.4XP_006512245.1  F-box and WD-40 domain protein 14 isoform X4

    Conserved Domains (1) summary
    pfam12937
    Location:446
    F-box-like
  2. XM_017313457.2XP_017168946.1  F-box and WD-40 domain protein 14 isoform X3

    Conserved Domains (1) summary
    pfam12937
    Location:446
    F-box-like
  3. XM_017313456.2XP_017168945.1  F-box and WD-40 domain protein 14 isoform X2

    Conserved Domains (2) summary
    COG2319
    Location:98234
    WD40; WD40 repeat [General function prediction only]
    pfam12937
    Location:446
    F-box-like
  4. XM_017313455.1XP_017168944.1  F-box and WD-40 domain protein 14 isoform X1

    Conserved Domains (1) summary
    pfam12937
    Location:446
    F-box-like