Fbh1 F-box DNA helicase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbh1provided by MGI
Official Full Name: F-box DNA helicase 1provided by MGI
Primary source: MGI:MGI:1354699
See related: Ensembl:ENSMUSG00000058594 AllianceGenome:MGI:1354699
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fbx18; Fbxo18
Summary: Predicted to enable ATP-dependent activity, acting on DNA and DNA binding activity. Involved in negative regulation of double-strand break repair via homologous recombination; replication fork processing; and replication fork protection. Acts upstream of or within negative regulation of chromatin binding activity and response to intra-S DNA damage checkpoint signaling. Predicted to be located in chromatin and nucleus. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBH1 (F-box DNA helicase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E14 (RPKM 14.0), limb E14.5 (RPKM 13.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2; 2 A1

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (11747384..11782396, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (11742573..11777585, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FBH1 restraining RAD51 DNA binding under unperturbed growth conditions to prevent unwanted or unscheduled DNA recombination.
Title: FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells.
FBH1 helicase activity is required to eliminate cells with excessive replication stress through the generation of MUS81-induced DNA double-strand breaks.
Title: FBH1 co-operates with MUS81 in inducing DNA double-strand breaks and cell death following replication stress.
role of the F-box helicase 1 (Fbh1) protein during genome maintenance in mammalian cells
Title: Mammalian Fbh1 is important to restore normal mitotic progression following decatenation stress.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Homology

Homologs of the Fbh1 gene: The Fbh1 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 487 organisms have orthologs with human gene Fbh1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5' DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables 3'-5' DNA helicase activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	ISO Inferred from Sequence Orthology more info
enables DNA translocase activity	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
involved_in cell death	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within negative regulation of chromatin binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in replication fork processing	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in replication fork processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in replication fork processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to intra-S DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to intra-S DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: F-box DNA helicase 1

Names: DNA 3'-5' helicase 1; F-box only protein 18; F-box protein 18

NP_001335163.1

EC 5.6.2.4

NP_001335164.1

EC 5.6.2.4

NP_001335165.1

EC 5.6.2.4

NP_001335166.1

EC 5.6.2.4

NP_056607.1

EC 5.6.2.4

XP_006497568.1

EC 5.6.2.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001348234.1 → NP_001335163.1 F-box DNA helicase 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL831794, AL845548

Conserved Domains (2) summary

COG0210
Location:365 → 857

UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]

pfam12937
Location:136 → 183

F-box-like; F-box-like
NM_001348235.1 → NP_001335164.1 F-box DNA helicase 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL831794, AL845548

Conserved Domains (2) summary

COG0210
Location:365 → 857

UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]

pfam12937
Location:136 → 183

F-box-like; F-box-like
NM_001348236.1 → NP_001335165.1 F-box DNA helicase 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL831794, AL845548

Conserved Domains (2) summary

COG0210
Location:365 → 857

UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]

pfam12937
Location:136 → 183

F-box-like; F-box-like
NM_001348237.1 → NP_001335166.1 F-box DNA helicase 1 isoform 2

Status: VALIDATED

Source sequence(s)

AK158937, AL831794, AL845548

Conserved Domains (2) summary

COG0210
Location:365 → 857

UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]

pfam12937
Location:136 → 183

F-box-like; F-box-like
NM_015792.2 → NP_056607.1 F-box DNA helicase 1 isoform 1

See identical proteins and their annotated locations for NP_056607.1

Status: VALIDATED

Source sequence(s)

AK003964, AK147829, AL831794, AL845548

Consensus CDS

CCDS15688.1

UniProtKB/Swiss-Prot

Q8K2I9, Q9QZG7

UniProtKB/TrEMBL

Q3UGP2

Related

ENSMUSP00000071495.8, ENSMUST00000071564.14

Conserved Domains (4) summary

COG0210
Location:439 → 931

UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]

pfam12937
Location:210 → 259

F-box-like; F-box-like

pfam13538
Location:870 → 931

UvrD_C_2; UvrD-like helicase C-terminal domain

cl21455
Location:440 → 684

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

11747384..11782396 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497505.3 → XP_006497568.1 F-box DNA helicase 1 isoform X1

Conserved Domains (3) summary

COG0210
Location:439 → 931

UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]

cd18786
Location:835 → 932

SF1_C; C-terminal helicase domain of superfamily 1 DEAD/H-box helicases

pfam12937
Location:210 → 257

F-box-like