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Fbxw7 F-box and WD-40 domain protein 7 [ Mus musculus (house mouse) ]

Gene ID: 50754, updated on 8-Dec-2022

Summary

Official Symbol
Fbxw7provided by MGI
Official Full Name
F-box and WD-40 domain protein 7provided by MGI
Primary source
MGI:MGI:1354695
See related
Ensembl:ENSMUSG00000028086 AllianceGenome:MGI:1354695
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AGO; Cdc4; Fbw7; Fbwd6; Fbx30; Fbxw6; Fbxo30; SEL-10; 1110001A17Rik
Summary
Predicted to enable several functions, including cyclin binding activity; phosphothreonine residue binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of osteoclast development; and positive regulation of proteolysis involved in cellular protein catabolic process. Acts upstream of or within several processes, including negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding activity; protein destabilization; and vasculogenesis. Located in several cellular components, including Golgi apparatus; nucleolus; and perinuclear region of cytoplasm. Is expressed in brain; early conceptus; genitourinary system; and skeletal muscle tissue. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 16.6), frontal lobe adult (RPKM 13.5) and 26 other tissues See more
Orthologs
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Genomic context

See Fbxw7 in Genome Data Viewer
Location:
3 F1; 3 37.7 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (84721901..84886505)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (84814990..84979198)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40079 Neighboring gene predicted gene, 35486 Neighboring gene predicted gene, 40080 Neighboring gene predicted gene, 46808 Neighboring gene predicted gene, 30944 Neighboring gene predicted gene, 30991

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (14)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphothreonine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to UV ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of osteoclast development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of osteoclast development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epidermal growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein destabilization IDA
Inferred from Direct Assay
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein ubiquitination ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of autophagy of mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell migration involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sister chromatid cohesion ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin recycling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
F-box/WD repeat-containing protein 7
Names
F-box and WD-40 domain protein 7, archipelago homolog
F-box and WD-40 domain-containing protein 7
F-box-WD40 repeat protein 6
f-box only protein 30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177773.1NP_001171244.1  F-box/WD repeat-containing protein 7 isoform 1

    See identical proteins and their annotated locations for NP_001171244.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' UTR, as compared to variant 1. Both variants 1 and 2 encode the same isoform 1.
    Source sequence(s)
    BC060620, BC066093
    Consensus CDS
    CCDS50940.1
    UniProtKB/Swiss-Prot
    Q8VHP4
    UniProtKB/TrEMBL
    D3YUA5
    Related
    ENSMUSP00000103306.2, ENSMUST00000107679.8
    Conserved Domains (3) summary
    cd00200
    Location:377653
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:387422
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:284328
    F-box-like
  2. NM_001177774.1NP_001171245.1  F-box/WD repeat-containing protein 7 isoform 1

    See identical proteins and their annotated locations for NP_001171245.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same isoform (1).
    Source sequence(s)
    BC066093
    Consensus CDS
    CCDS50940.1
    UniProtKB/Swiss-Prot
    Q8VHP4
    UniProtKB/TrEMBL
    D3YUA5
    Related
    ENSMUSP00000103305.2, ENSMUST00000107678.8
    Conserved Domains (3) summary
    cd00200
    Location:377653
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:387422
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:284328
    F-box-like
  3. NM_080428.3NP_536353.2  F-box/WD repeat-containing protein 7 isoform 2

    See identical proteins and their annotated locations for NP_536353.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a few of 5' exons, but has an alternate 5' exon including coding region, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.
    Source sequence(s)
    AF391192, BC066093
    Consensus CDS
    CCDS17440.1
    UniProtKB/Swiss-Prot
    Q8VBV4
    UniProtKB/TrEMBL
    A0A6P7R0P4, A0A8C6HPM9
    Related
    ENSMUSP00000029727.8, ENSMUST00000029727.8
    Conserved Domains (3) summary
    cd00200
    Location:296572
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:306341
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:203247
    F-box-like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    84721901..84886505
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501657.5XP_006501720.1  F-box/WD repeat-containing protein 7 isoform X1

    See identical proteins and their annotated locations for XP_006501720.1

    UniProtKB/Swiss-Prot
    Q8VHP4
    UniProtKB/TrEMBL
    D3YUA5
    Conserved Domains (3) summary
    cd00200
    Location:377653
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:387422
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:284328
    F-box-like
  2. XM_006501656.4XP_006501719.1  F-box/WD repeat-containing protein 7 isoform X1

    See identical proteins and their annotated locations for XP_006501719.1

    UniProtKB/Swiss-Prot
    Q8VHP4
    UniProtKB/TrEMBL
    D3YUA5
    Conserved Domains (3) summary
    cd00200
    Location:377653
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:387422
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:284328
    F-box-like
  3. XM_006501658.4XP_006501721.1  F-box/WD repeat-containing protein 7 isoform X2

    UniProtKB/TrEMBL
    A0A6P7QSW5, A0A8C6HPK9, D3YUA8
    Related
    ENSMUSP00000103302.2, ENSMUST00000107675.8
    Conserved Domains (3) summary
    cd00200
    Location:256532
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:266301
    7WD40; WD40 repeat [structural motif]
    pfam12937
    Location:163207
    F-box-like