Fbxo8 F-box protein 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbxo8provided by MGI
Official Full Name: F-box protein 8provided by MGI
Primary source: MGI:MGI:1354696
See related: Ensembl:ENSMUSG00000038206 AllianceGenome:MGI:1354696
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fbx8
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within ubiquitin-dependent protein catabolic process. Part of ubiquitin ligase complex. Is expressed in several structures, including branchial arch; ear; forelimb bud; heart; and notochord. Orthologous to human FBXO8 (F-box protein 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 8.5), kidney adult (RPKM 7.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8; 8 B2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (57004189..57046974)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (56551154..56593939)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fbx8, an F-box protein bearing the Sec7 domain, mediates ubiquitination of Arf6.
Title: Fbx8 makes Arf6 refractory to function via ubiquitination.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141026 (e-PCR)
- UniSTS:223026

NoName (e-PCR)
- UniSTS:235894

45.MMHAP84FLG6.seq (e-PCR)
- UniSTS:124596

Homology

Homologs of the Fbxo8 gene: The Fbxo8 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 491 organisms have orthologs with human gene Fbxo8
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of ARF protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of ubiquitin ligase complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: F-box only protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368347.1 → NP_001355276.1 F-box only protein 8 isoform 2

Status: VALIDATED

Source sequence(s)

AC116121

UniProtKB/TrEMBL

A0A6P7R6I5

Conserved Domains (1) summary

cd00171
Location:1 → 155

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
NM_001368348.1 → NP_001355277.1 F-box only protein 8 isoform 2

Status: VALIDATED

Source sequence(s)

AC116121

UniProtKB/TrEMBL

A0A6P7R6I5

Conserved Domains (1) summary

cd00171
Location:1 → 155

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
NM_015791.4 → NP_056606.2 F-box only protein 8 isoform 1

See identical proteins and their annotated locations for NP_056606.2

Status: VALIDATED

Source sequence(s)

AC116121

Consensus CDS

CCDS22314.1

UniProtKB/Swiss-Prot

Q8JZY7, Q9QZN3

UniProtKB/TrEMBL

A0A6P5QCZ4

Related

ENSMUSP00000037544.6, ENSMUST00000040218.13

Conserved Domains (2) summary

cd00171
Location:133 → 312

Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

pfam12937
Location:74 → 112

F-box-like