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PAWR pro-apoptotic WT1 regulator [ Homo sapiens (human) ]

Gene ID: 5074, updated on 27-Nov-2024

Summary

Official Symbol
PAWRprovided by HGNC
Official Full Name
pro-apoptotic WT1 regulatorprovided by HGNC
Primary source
HGNC:HGNC:8614
See related
Ensembl:ENSG00000177425 MIM:601936; AllianceGenome:HGNC:8614
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAR4; Par-4
Summary
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]
Expression
Ubiquitous expression in endometrium (RPKM 8.7), thyroid (RPKM 5.9) and 24 other tissues See more
Orthologs
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Genomic context

See PAWR in Genome Data Viewer
Location:
12q21.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (79584879..79690964, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (79563553..79669620, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (79978659..80084744, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene synaptotagmin 1 Neighboring gene microRNA 1252 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:79906476-79906976 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:79906977-79907477 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:79926619-79927119 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:79933315-79933826 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:79933827-79934340 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:79936391-79936902 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:79938953-79939466 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:79941058-79941786 Neighboring gene NOP56 ribonucleoprotein pseudogene 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:80048601-80049285 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4681 Neighboring gene PPP1R12A antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4682 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:80104382-80104890 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:80177965-80178557 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:80178558-80179149 Neighboring gene uncharacterized LOC124902974 Neighboring gene protein phosphatase 1 regulatory subunit 12A Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:80268321-80268858 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:80268859-80269395 Neighboring gene RNA, 5S ribosomal pseudogene 363

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Par-4 expression is upregulated by HIV-1 Tat in hippocampal neurons and participates at an early stage of Tat-induced neuronal apoptosis, suggesting Par-4 may be a mediator of neuronal apoptosis in HIV encephalitis PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables enzyme binding IDA
Inferred from Direct Assay
more info
PubMed 
enables leucine zipper domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament bundle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of amyloid precursor protein biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of cellular senescence IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of hydrogen peroxide-mediated programmed cell death IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with actin filament ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in chromatin IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
PRKC apoptosis WT1 regulator protein
Names
PRKC, apoptosis, WT1, regulator
WT1-interacting protein
prostate apoptosis response protein 4
prostate apoptosis response protein PAR-4
prostate apoptosis response-4
transcriptional repressor PAR4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001354732.2NP_001341661.1  PRKC apoptosis WT1 regulator protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC027288, AC073569, AC073595
    Consensus CDS
    CCDS31863.1
    UniProtKB/Swiss-Prot
    O75796, Q6FHY9, Q8N700, Q96IZ0
    Conserved Domains (1) summary
    pfam05911
    Location:268327
    FPP; Filament-like plant protein, long coiled-coil
  2. NM_001354733.2NP_001341662.1  PRKC apoptosis WT1 regulator protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC073569, AC073595
  3. NM_002583.4NP_002574.2  PRKC apoptosis WT1 regulator protein isoform 1

    See identical proteins and their annotated locations for NP_002574.2

    Status: REVIEWED

    Source sequence(s)
    AC027288, BC007018, CN280333, U63809
    Consensus CDS
    CCDS31863.1
    UniProtKB/Swiss-Prot
    O75796, Q6FHY9, Q8N700, Q96IZ0
    Related
    ENSP00000328088.4, ENST00000328827.9
    Conserved Domains (1) summary
    pfam05911
    Location:268327
    FPP; Filament-like plant protein, long coiled-coil

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    79584879..79690964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428916.1XP_047284872.1  PRKC apoptosis WT1 regulator protein isoform X1

    UniProtKB/Swiss-Prot
    O75796, Q6FHY9, Q8N700, Q96IZ0
  2. XM_047428918.1XP_047284874.1  PRKC apoptosis WT1 regulator protein isoform X2

  3. XM_047428917.1XP_047284873.1  PRKC apoptosis WT1 regulator protein isoform X2

  4. XM_017019378.2XP_016874867.1  PRKC apoptosis WT1 regulator protein isoform X3

  5. XM_047428919.1XP_047284875.1  PRKC apoptosis WT1 regulator protein isoform X3

  6. XM_017019379.2XP_016874868.1  PRKC apoptosis WT1 regulator protein isoform X4

RNA

  1. XR_944561.3 RNA Sequence

  2. XR_944560.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    79563553..79669620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372151.1XP_054228126.1  PRKC apoptosis WT1 regulator protein isoform X1

    UniProtKB/Swiss-Prot
    O75796, Q6FHY9, Q8N700, Q96IZ0
  2. XM_054372152.1XP_054228127.1  PRKC apoptosis WT1 regulator protein isoform X2

  3. XM_054372153.1XP_054228128.1  PRKC apoptosis WT1 regulator protein isoform X3

  4. XM_054372154.1XP_054228129.1  PRKC apoptosis WT1 regulator protein isoform X4

RNA

  1. XR_008488595.1 RNA Sequence

  2. XR_008488594.1 RNA Sequence