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PAWR pro-apoptotic WT1 regulator [ Homo sapiens (human) ]

Gene ID: 5074, updated on 8-Jul-2018
Official Symbol
PAWRprovided by HGNC
Official Full Name
pro-apoptotic WT1 regulatorprovided by HGNC
Primary source
HGNC:HGNC:8614
See related
Ensembl:ENSG00000177425 MIM:601936; Vega:OTTHUMG00000170080
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAR4; Par-4
Summary
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]
Expression
Ubiquitous expression in endometrium (RPKM 8.7), thyroid (RPKM 5.9) and 24 other tissues See more
Orthologs
See PAWR in Genome Data Viewer
Location:
12q21.2
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (79584874..79691097, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (79985745..80084877, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene synaptotagmin 1 Neighboring gene microRNA 1252 Neighboring gene NOP56 ribonucleoprotein pseudogene 3 Neighboring gene uncharacterized LOC105369864 Neighboring gene protein phosphatase 1 regulatory subunit 12A Neighboring gene RNA, 5S ribosomal pseudogene 363

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat Par-4 expression is upregulated by HIV-1 Tat in hippocampal neurons and participates at an early stage of Tat-induced neuronal apoptosis, suggesting Par-4 may be a mediator of neuronal apoptosis in HIV encephalitis PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enzyme binding IDA
Inferred from Direct Assay
more info
PubMed 
leucine zipper domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
actin filament bundle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
interleukin-2 biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of amyloid precursor protein biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of cellular senescence IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hydrogen peroxide-mediated programmed cell death IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with actin filament ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
PRKC apoptosis WT1 regulator protein
Names
PRKC, apoptosis, WT1, regulator
WT1-interacting protein
prostate apoptosis response protein 4
prostate apoptosis response protein PAR-4
prostate apoptosis response-4
transcriptional repressor PAR4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001354732.1NP_001341661.1  PRKC apoptosis WT1 regulator protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC027288, AC073569, AC073595
    Consensus CDS
    CCDS31863.1
    Conserved Domains (1) summary
    pfam05911
    Location:268327
    FPP; Filament-like plant protein, long coiled-coil
  2. NM_001354733.1NP_001341662.1  PRKC apoptosis WT1 regulator protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC073569, AC073595
  3. NM_002583.3NP_002574.2  PRKC apoptosis WT1 regulator protein isoform 1

    See identical proteins and their annotated locations for NP_002574.2

    Status: REVIEWED

    Source sequence(s)
    AC027288, BC007018, CN280333, HY035045, U63809
    Consensus CDS
    CCDS31863.1
    UniProtKB/Swiss-Prot
    Q96IZ0
    Related
    ENSP00000328088.4, OTTHUMP00000242764, ENST00000328827.8
    Conserved Domains (1) summary
    pfam05911
    Location:268327
    FPP; Filament-like plant protein, long coiled-coil

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    79584874..79691097 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719435.2XP_006719498.1  PRKC apoptosis WT1 regulator protein isoform X1

    See identical proteins and their annotated locations for XP_006719498.1

    UniProtKB/Swiss-Prot
    Q96IZ0
    Conserved Domains (1) summary
    pfam05911
    Location:268327
    FPP; Filament-like plant protein, long coiled-coil
  2. XM_017019378.1XP_016874867.1  PRKC apoptosis WT1 regulator protein isoform X2

  3. XM_017019379.1XP_016874868.1  PRKC apoptosis WT1 regulator protein isoform X3

RNA

  1. XR_944561.2 RNA Sequence

  2. XR_944560.2 RNA Sequence

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