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H1f4 H1.4 linker histone, cluster member [ Mus musculus (house mouse) ]

Gene ID: 50709, updated on 8-Jan-2023

Summary

Official Symbol
H1f4provided by MGI
Official Full Name
H1.4 linker histone, cluster memberprovided by MGI
Primary source
MGI:MGI:1931527
See related
Ensembl:ENSMUSG00000051627 AllianceGenome:MGI:1931527
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H1e; H1-4; H1.4; H1s-4; H1var2; H1 VAR.2; Hist1h1e
Summary
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]
Orthologs
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Genomic context

See H1f4 in Genome Data Viewer
Location:
13; 13 A3.1
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (23805760..23806541, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (23621777..23622558, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene H4 clustered histone 4 Neighboring gene H2B clustered histone 6 Neighboring gene predicted gene, 33387 Neighboring gene predicted gene, 22452 Neighboring gene H2A clustered histone 6

Genomic regions, transcripts, and products

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP binding ISO
Inferred from Sequence Orthology
more info
 
enables AMP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables dATP binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of chromatin IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in heterochromatin ISO
Inferred from Sequence Orthology
more info
 
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone H1.4
Names
H1 histone family, member 4
histone 1, H1e
histone H1e
histone cluster 1, H1e

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015787.4NP_056602.1  histone H1.4

    See identical proteins and their annotated locations for NP_056602.1

    Status: REVIEWED

    Source sequence(s)
    AL592149
    Consensus CDS
    CCDS26355.1
    UniProtKB/Swiss-Prot
    P43274, Q5EBH3
    UniProtKB/TrEMBL
    A0A8C6GAI4
    Related
    ENSMUSP00000057308.3, ENSMUST00000062045.4
    Conserved Domains (1) summary
    pfam00538
    Location:38108
    Linker_histone; linker histone H1 and H5 family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    23805760..23806541 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)