U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mapk3 mitogen activated protein kinase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 50689, updated on 1-Oct-2024

Summary

Official Symbol
Mapk3provided by RGD
Official Full Name
mitogen activated protein kinase 3provided by RGD
Primary source
RGD:3046
See related
EnsemblRapid:ENSRNOG00000053583 AllianceGenome:RGD:3046
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
p44; ERK1; ERT2; MNK1; Erk-1; Esrk1; MAPK1; Prkm3; p44erk1; p44mapk
Summary
Enables ATP binding activity; MAP kinase activity; and scaffold protein binding activity. Involved in several processes, including arachidonic acid metabolic process; decidualization; and peptidyl-serine phosphorylation. Located in caveola; cytosol; and nucleoplasm. Part of protein-containing complex. Used to study gastric ulcer; middle cerebral artery infarction; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; endometrial adenocarcinoma; pancreatic ductal carcinoma; and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 210.4), Brain (RPKM 104.7) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Mapk3 in Genome Data Viewer
Location:
1q36
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190797189..190803411)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181366646..181372863)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198192773..198198975)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349642 Neighboring gene large ribosomal subunit protein uL2-like Neighboring gene large ribosomal subunit protein eL18-like Neighboring gene glycerophosphodiester phosphodiesterase domain containing 3 Neighboring gene yippee-like 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IC
Inferred by Curator
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Bergmann glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in ERBB2-ERBB3 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in Schwann cell development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in arachidonate metabolic process IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within cardiac neural crest cell development involved in heart development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cartilage development ISO
Inferred from Sequence Orthology
more info
 
involved_in caveolin-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in caveolin-mediated endocytosis TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to toxic substance IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in decidualization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within face development ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lung morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in myelination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural crest cell development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within outer ear morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-tyrosine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cyclase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of macrophage proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of xenophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Golgi inheritance IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of Golgi inheritance TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of cellular pH ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of early endosome to late endosome transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of early endosome to late endosome transport TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of stress-activated MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of stress-activated MAPK cascade TAS
Traceable Author Statement
more info
PubMed 
involved_in response to epidermal growth factor ISO
Inferred from Sequence Orthology
more info
 
involved_in response to epidermal growth factor ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within response to exogenous dsRNA ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in response to toxic substance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
involved_in stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within thymus development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within thyroid gland development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within trachea formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of xenophagy ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in caveola IEA
Inferred from Electronic Annotation
more info
 
located_in caveola TAS
Traceable Author Statement
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome TAS
Traceable Author Statement
more info
PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 
located_in focal adhesion TAS
Traceable Author Statement
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome TAS
Traceable Author Statement
more info
PubMed 
located_in mitochondrion TAS
Traceable Author Statement
more info
PubMed 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in pseudopodium ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase 3
Names
MAP kinase 1
MAP kinase 3
MAPK 1
MAPK 3
extracellular signal-regulated kinase 1
insulin-stimulated MAP2 kinase
microtubule-associated protein 2 kinase
mitogen-activated 3
mitogen-activated protein kinase 1
NP_059043.2
XP_038944453.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017347.3NP_059043.2  mitogen-activated protein kinase 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    P21708, Q4PIY8, Q62686, Q9JJ13
    UniProtKB/TrEMBL
    A0A8L2R3C3
    Related
    ENSRNOP00000026688.8, ENSRNOT00000026688.8
    Conserved Domains (1) summary
    cd07849
    Location:37371
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    190797189..190803411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088525.2XP_038944453.1  mitogen-activated protein kinase 3 isoform X1

    UniProtKB/TrEMBL
    A0A8L2R3C3
    Related
    ENSRNOP00000110992.1, ENSRNOT00000165309.1
    Conserved Domains (1) summary
    cd07849
    Location:37397
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases