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Runx1 RUNX family transcription factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 50662, updated on 6-May-2021

Summary

Official Symbol
Runx1provided by RGD
Official Full Name
RUNX family transcription factor 1provided by RGD
Primary source
RGD:2283
See related
Ensembl:ENSRNOG00000001704
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
B; Aml1; Cbfa2; PEA2-alpha; CBF-alpha-2; PEBP2-alpha
Summary
putative transcription factor that may be involved in skeletal muscle gene regulation; human homolog is associated with a form of acute myeloid leukemia [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 80.8), Spleen (RPKM 41.6) and 6 other tissues See more
Orthologs
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Genomic context

See Runx1 in Genome Data Viewer
Location:
11q11
Exon count:
8
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (31839880..32074427, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (32765147..33003061, complement)

Chromosome 11 - NC_051346.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene chloride intracellular channel 6 Neighboring gene uncharacterized LOC120095627 Neighboring gene uncharacterized LOC102548550 Neighboring gene uncharacterized LOC102549086

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within behavioral response to pain ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within central nervous system development ISO
Inferred from Sequence Orthology
more info
 
involved_in chondrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within definitive hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hair follicle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in hemopoiesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within liver development ISO
Inferred from Sequence Orthology
more info
 
involved_in myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in myeloid leukocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myeloid progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of CD4-positive, alpha-beta T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of CD4-positive, alpha-beta T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of granulocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron development ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron fate commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in ossification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ovulation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of CD8-positive, alpha-beta T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of CD8-positive, alpha-beta T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of cell maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of granulocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of granulocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interferon-gamma production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of progesterone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of T cell anergy ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of hair follicle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in response to denervation involved in regulation of muscle adaptation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal system development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
part_of core-binding factor complex TAS
Traceable Author Statement
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
runt-related transcription factor 1
Names
PEA2-alpha B
PEBP2-alpha B
acute myeloid leukemia 1 protein
core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene)
core-binding factor subunit alpha-2
oncogene AML-1
polyomavirus enhancer-binding protein 2 alpha B subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017325.2NP_059021.1  runt-related transcription factor 1

    See identical proteins and their annotated locations for NP_059021.1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000222
    UniProtKB/Swiss-Prot
    Q63046
    Related
    ENSRNOP00000002313.3, ENSRNOT00000002313.4
    Conserved Domains (2) summary
    pfam00853
    Location:58179
    Runt; Runt domain
    pfam08504
    Location:360450
    RunxI; Runx inhibition domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051346.1 Reference mRatBN7.2 Primary Assembly

    Range
    31839880..32074427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008768599.3XP_008766821.2  runt-related transcription factor 1 isoform X3

  2. XM_008768598.3XP_008766820.2  runt-related transcription factor 1 isoform X2

  3. XM_017598053.2XP_017453542.1  runt-related transcription factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYQ4
    Related
    ENSRNOP00000070750.1
    Conserved Domains (2) summary
    pfam00853
    Location:68194
    Runt; Runt domain
    pfam08504
    Location:374464
    RunxI; Runx inhibition domain
  4. XM_039088599.1XP_038944527.1  runt-related transcription factor 1 isoform X1

    Conserved Domains (2) summary
    pfam00853
    Location:68194
    Runt; Runt domain
    pfam08504
    Location:374464
    RunxI; Runx inhibition domain
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