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Nr2c2 nuclear receptor subfamily 2, group C, member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 50659, updated on 27-Nov-2024

Summary

Official Symbol
Nr2c2provided by RGD
Official Full Name
nuclear receptor subfamily 2, group C, member 2provided by RGD
Primary source
RGD:3201
See related
EnsemblRapid:ENSRNOG00000010536 AllianceGenome:RGD:3201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tr4
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear receptor activity. Predicted to be involved in several processes, including p38MAPK cascade; positive regulation of myoblast differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within lipopolysaccharide-mediated signaling pathway; meiotic cell cycle; and spermatogenesis. Predicted to be located in nucleoplasm. Orthologous to human NR2C2 (nuclear receptor subfamily 2 group C member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 236.9), Brain (RPKM 235.2) and 9 other tissues See more
Orthologs
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Genomic context

See Nr2c2 in Genome Data Viewer
Location:
4q34
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (126167350..126223942)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (124610216..124666813)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (124005287..124030349)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 3 open reading frame 20 Neighboring gene uncharacterized LOC102554857 Neighboring gene FYVE, RhoGEF and PH domain containing 5 Neighboring gene uncharacterized LOC134486612 Neighboring gene mitochondrial ribosomal protein S25 Neighboring gene uncharacterized LOC103692187 Neighboring gene rabenosyn, RAB effector

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cerebellum development ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within meiotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of embryonic development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nuclear receptor subfamily 2 group C member 2
Names
TR4 orphan receptor
TR4-NS orphan receptor
orphan nuclear receptor TR4
orphan receptor TR4
testicular receptor 4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017323.2NP_059019.2  nuclear receptor subfamily 2 group C member 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    P55094
    UniProtKB/TrEMBL
    A6IBC1, G3V7F5
    Conserved Domains (2) summary
    cd06952
    Location:361582
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:112198
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    126167350..126223942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108274.2XP_038964202.1  nuclear receptor subfamily 2 group C member 2 isoform X2

    UniProtKB/Swiss-Prot
    P55094
    UniProtKB/TrEMBL
    A6IBC1, G3V7F5
    Conserved Domains (2) summary
    cd06952
    Location:361582
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:112198
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  2. XM_039108276.2XP_038964204.1  nuclear receptor subfamily 2 group C member 2 isoform X2

    UniProtKB/Swiss-Prot
    P55094
    UniProtKB/TrEMBL
    A6IBC1, G3V7F5
    Conserved Domains (2) summary
    cd06952
    Location:361582
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:112198
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  3. XM_039108269.2XP_038964197.1  nuclear receptor subfamily 2 group C member 2 isoform X2

    UniProtKB/Swiss-Prot
    P55094
    UniProtKB/TrEMBL
    A6IBC1, G3V7F5
    Conserved Domains (2) summary
    cd06952
    Location:361582
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:112198
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  4. XM_039108266.2XP_038964194.1  nuclear receptor subfamily 2 group C member 2 isoform X1

    UniProtKB/Swiss-Prot
    P55094
    UniProtKB/TrEMBL
    A0A8I6AGK0, A6IBB9
    Related
    ENSRNOP00000014354.4, ENSRNOT00000014353.7
    Conserved Domains (2) summary
    cd06952
    Location:394615
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:145231
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  5. XM_039108275.2XP_038964203.1  nuclear receptor subfamily 2 group C member 2 isoform X2

    UniProtKB/Swiss-Prot
    P55094
    UniProtKB/TrEMBL
    A6IBC1, G3V7F5
    Related
    ENSRNOP00000091661.2, ENSRNOT00000106878.2
    Conserved Domains (2) summary
    cd06952
    Location:361582
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:112198
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
  6. XM_039108273.1XP_038964201.1  nuclear receptor subfamily 2 group C member 2 isoform X2

    UniProtKB/Swiss-Prot
    P55094
    UniProtKB/TrEMBL
    A6IBC1, G3V7F5
    Conserved Domains (2) summary
    cd06952
    Location:361582
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:112198
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers