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Mapk9 mitogen-activated protein kinase 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 50658, updated on 5-Jan-2022

Summary

Official Symbol
Mapk9provided by RGD
Official Full Name
mitogen-activated protein kinase 9provided by RGD
Primary source
RGD:628847
See related
Ensembl:ENSRNOG00000002823
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SAPK
Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases are multifunctional proteins. They are involved in a wide variety of cellular processes such as growth, proliferation, differentiation, transcription regulation, and development. They function in stress responses, apoptosis, inflammation and transformation. For example, this kinase plays a dominant role in mediating proliferation of lung cancer and prostate cancer cells, and in regulation of osmotic stress-induced tight junction disruption. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2012]
Expression
Biased expression in Brain (RPKM 297.8), Liver (RPKM 173.0) and 9 other tissues See more
Orthologs
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Genomic context

See Mapk9 in Genome Data Viewer
Location:
10q21
Exon count:
15
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (34169661..34211138)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (35333859..35374364)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L29-like Neighboring gene uncharacterized LOC120095088 Neighboring gene glutamine-fructose-6-phosphate transaminase 2 Neighboring gene uncharacterized LOC120095089 Neighboring gene microRNA 336 Neighboring gene RasGEF domain family, member 1C Neighboring gene ring finger protein 130 Neighboring gene microRNA mir-340-1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables JUN kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type endopeptidase activator activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables mitogen-activated protein kinase kinase kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine/tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in JNK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in JUN phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular hyperosmotic response IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to UV IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to amyloid-beta IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to cadmium ion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to reactive oxygen species IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in central nervous system development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell morphogenesis involved in differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage derived foam cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nitric-oxide synthase biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of podosome assembly IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of podosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of prostaglandin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of prostaglandin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription factor catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription factor catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to tricellular tight junction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein localization to tricellular tight junction ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting to mitochondrion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in release of cytochrome c from mitochondria IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to amine IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nerve growth factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to water deprivation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase 9
Names
MAP kinase 9
MAPK 9
SAPK-alpha
c-Jun N-terminal kinase 2
p54-alpha
stress activated protein kinase alpha II
stress-activated protein kinase JNK2
NP_001257473.1
NP_001257474.1
NP_059018.1
XP_006246380.1
XP_017452968.1
XP_038942586.1
XP_038942587.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270544.1NP_001257473.1  mitogen-activated protein kinase 9 isoform 2

    See identical proteins and their annotated locations for NP_001257473.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate exon in the coding region, compared to variant 1. The resulting isoform (2) is of the same size, but has a different internal segment, compared to isoform 1.
    Source sequence(s)
    BC061870, BI282175, DN948189, JACYVU010000219, L27111
    UniProtKB/Swiss-Prot
    P49186
    UniProtKB/TrEMBL
    D4A5V8, Q6P727
    Related
    ENSRNOP00000004010.4, ENSRNOT00000004010.5
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  2. NM_001270545.1NP_001257474.1  mitogen-activated protein kinase 9 isoform 3

    See identical proteins and their annotated locations for NP_001257474.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is the longer transcript and has an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC061870, BI282175, DN948189, JACYVU010000219
    UniProtKB/TrEMBL
    Q6P727
    Related
    ENSRNOP00000003987.3, ENSRNOT00000003987.6
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  3. NM_017322.2NP_059018.1  mitogen-activated protein kinase 9 isoform 1

    See identical proteins and their annotated locations for NP_059018.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC061870, BI282175, DN948189, JACYVU010000219, L27112
    UniProtKB/Swiss-Prot
    P49186
    UniProtKB/TrEMBL
    Q6P727
    Related
    ENSRNOP00000087042.1, ENSRNOT00000116124.1
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    34169661..34211138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017597479.2XP_017452968.1  mitogen-activated protein kinase 9 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:25210
    PKc_like; Protein Kinases, catalytic domain
  2. XM_039086659.1XP_038942587.1  mitogen-activated protein kinase 9 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1240
    PKc_like; Protein Kinases, catalytic domain
  3. XM_039086658.1XP_038942586.1  mitogen-activated protein kinase 9 isoform X2

    Conserved Domains (1) summary
    cd07850
    Location:16334
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  4. XM_006246318.4XP_006246380.1  mitogen-activated protein kinase 9 isoform X1

    See identical proteins and their annotated locations for XP_006246380.1

    UniProtKB/TrEMBL
    A0A0G2JYS4
    Related
    ENSRNOP00000090510.1, ENSRNOT00000107644.1
    Conserved Domains (1) summary
    cd07850
    Location:16334
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
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