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KRT18 keratin 18 [ Bos taurus (domestic cattle) ]

Gene ID: 506480, updated on 30-Jan-2025
Official Symbol
KRT18provided by VGNC
Official Full Name
keratin 18provided by VGNC
Primary source
VGNC:VGNC:30719
See related
BGD:BT14409; EnsemblRapid:ENSBTAG00070034509
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See KRT18 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (26998520..27002170, complement)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene tensin 2 Neighboring gene uncharacterized LOC132345256 Neighboring gene eukaryotic translation initiation factor 4B Neighboring gene uncharacterized LOC104976949 Neighboring gene keratin 8

Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ezrin and CK18 are downregulated during implantation in cattle. The expression changes represent a temporal depolarization, which could be important for an establishment of bovine pregnancy.
    Title: Changes in endometrial ezrin and cytokeratin 18 expression during bovine implantation and in caruncular endometrial spheroids in vitro.
  2. Results did not support that K8/K18 filaments influence the expression of Fas on the surface of luteal cells.
    Title: Estrous cycle-dependent changes of Fas expression in the bovine corpus luteum: influence of keratin 8/18 intermediate filaments and cytokines.
  3. Data indicate that CK18 may be a molecular marker for bovine M cells in follicule-associated epithelium of Peyer's patches.
    Title: Cytokeratin 18 is a specific marker of bovine intestinal M cell.
  4. KRT18 knockdown in preimplantation embryos results in reduced blastocyst formation, but no further morphological aberrations were observed with regard to the biological function of KRT18.
    Title: Suppression of keratin 18 gene expression in bovine blastocysts by RNA interference.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intermediate filament cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
keratin, type I cytoskeletal 18
Names
cytokeratin 18

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001192095.1 → NP_001179024.1  keratin, type I cytoskeletal 18

    See identical proteins and their annotated locations for NP_001179024.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000005
    UniProtKB/TrEMBL
    F6S1Q0
    Related
    ENSBTAP00070047339.1, ENSBTAT00070077578.1
    Conserved Domains (2) summary
    pfam00038
    Location:79 → 389
    Filament; Intermediate filament protein
    cl19252
    Location:147 → 289
    MreC; rod shape-determining protein MreC

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    26998520..27002170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials