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GSR glutathione-disulfide reductase [ Bos taurus (cattle) ]

Gene ID: 506406, updated on 27-Aug-2018

Summary

Official Symbol
GSRprovided by VGNC
Official Full Name
glutathione-disulfide reductaseprovided by VGNC
Primary source
VGNC:VGNC:29682
See related
BGD:BT27146; Ensembl:ENSBTAG00000007115
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs

Genomic context

See GSR in Genome Data Viewer
Location:
chromosome: 27
Exon count:
15
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 27 NC_037354.1 (26801918..26846927, complement)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 27 AC_000184.1 (25943355..25973543, complement)

Chromosome 27 - NC_037354.1Genomic Context describing neighboring genes Neighboring gene RNA binding protein, mRNA processing factor Neighboring gene microRNA 2399 Neighboring gene general transcription factor IIE subunit 2 Neighboring gene small integral membrane protein 18 Neighboring gene 60S ribosomal protein L26-like Neighboring gene UBX domain protein 8

Genomic regions, transcripts, and products

Pathways from BioSystems

General gene information

Homology

  • Homologs of the GSR gene: The GSR gene is conserved in human, chimpanzee, dog, mouse, rat, chicken, zebrafish, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs from Annotation Pipeline: 238 organisms have orthologs with human gene GSR

General protein information

Preferred Names
glutathione reductase, mitochondrial
Names
glutathione reductase
NP_001107662.1
XP_024841977.1
XP_024841978.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114190.2NP_001107662.1  glutathione reductase, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    DV820297, DV884056, EE253355, EH148178, EV753873, NKLS02000027
    Related
    ENSBTAP00000009363.5, ENSBTAT00000009363.5
    Conserved Domains (4) summary
    TIGR01421
    Location:61519
    gluta_reduc_1; glutathione-disulfide reductase, animal/bacterial
    pfam00070
    Location:230306
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam02852
    Location:409517
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
    cl21454
    Location:181243
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037354.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    26801918..26846927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024986210.1XP_024841978.1  glutathione reductase, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl27343
    Location:1410
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
  2. XM_024986209.1XP_024841977.1  glutathione reductase, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl27343
    Location:18442
    Pyr_redox_dim; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
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