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IL16 interleukin 16 [ Bos taurus (domestic cattle) ]

Gene ID: 506314, updated on 30-Jan-2025
Official Symbol
IL16provided by VGNC
Official Full Name
interleukin 16provided by VGNC
Primary source
VGNC:VGNC:53943
See related
BGD:BT11789; EnsemblRapid:ENSBTAG00070008509
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See IL16 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (26973354..27099796)

Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 161 Neighboring gene talin rod domain containing 1 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene COMM domain-containing protein 6-like Neighboring gene StAR related lipid transfer domain containing 5 Neighboring gene transmembrane channel like 3

Genomic Sequence:
NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Sequence evaluation of four pooled-tissue normalized bovine cDNA libraries and construction of a gene index for cattle. Smith TP, et al. Genome Res, 2001 Apr. PMID 11282978, Free PMC Article
  2. Characterization of 954 bovine full-CDS cDNA sequences. Harhay GP, et al. BMC Genomics, 2005 Nov 23. PMID 16305752, Free PMC Article
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables CD4 receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in induction of positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in leukocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
pro-interleukin-16
Names
interleukin 16 (lymphocyte chemoattractant factor)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001075253.2 → NP_001068721.1  pro-interleukin-16

    See identical proteins and their annotated locations for NP_001068721.1

    Status: VALIDATED

    Source sequence(s)
    BT026153, NKLS02000021
    UniProtKB/Swiss-Prot
    Q0V8R5
    Conserved Domains (4) summary
    smart00228
    Location:529 → 615
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:407 → 484
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam09770
    Location:135 → 271
    PAT1; Topoisomerase II-associated protein PAT1
    cl29137
    Location:175 → 239
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    26973354..27099796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059878979.1 → XP_059734962.1  pro-interleukin-16 isoform X5

    UniProtKB/TrEMBL
    A0AAF6YVJ6

  2. XM_024981655.2 → XP_024837423.1  pro-interleukin-16 isoform X1

    UniProtKB/TrEMBL
    A0AAF6YVJ6
    Conserved Domains (2) summary
    cd00992
    Location:1154 → 1231
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl28033
    Location:653 → 1018
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  3. XM_024981659.2 → XP_024837427.1  pro-interleukin-16 isoform X3

    UniProtKB/TrEMBL
    A0AAF6YVJ6
    Related
    ENSBTAP00070011382.1, ENSBTAT00070019230.1
    Conserved Domains (3) summary
    smart00228
    Location:1277 → 1363
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1154 → 1231
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl28033
    Location:653 → 1018
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  4. XM_024981657.2 → XP_024837425.1  pro-interleukin-16 isoform X2

    UniProtKB/TrEMBL
    A0AAF6YVJ6
    Conserved Domains (2) summary
    cd00992
    Location:1154 → 1231
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl28033
    Location:653 → 1018
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  5. XM_024981660.2 → XP_024837428.1  pro-interleukin-16 isoform X4

    UniProtKB/TrEMBL
    A0AAA9TS06, A0AAF6YVJ6
    Related
    ENSBTAP00070011406.1, ENSBTAT00070019281.1
    Conserved Domains (3) summary
    smart00228
    Location:1276 → 1362
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:1154 → 1231
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl28033
    Location:653 → 1018
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  6. XM_024981656.2 → XP_024837424.1  pro-interleukin-16 isoform X1

    UniProtKB/TrEMBL
    A0AAF6YVJ6
    Conserved Domains (2) summary
    cd00992
    Location:1154 → 1231
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl28033
    Location:653 → 1018
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0V8R5.1 GenPept UniProtKB/Swiss-Prot:Q0V8R5

Gene LinkOut

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Molecular Biology Databases
Research Materials