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CUZD1 CUB and zona pellucida like domains 1 [ Homo sapiens (human) ]

Gene ID: 50624, updated on 29-Mar-2018

Summary

Official Symbol
CUZD1provided by HGNC
Official Full Name
CUB and zona pellucida like domains 1provided by HGNC
Primary source
HGNC:HGNC:17937
See related
Ensembl:ENSG00000138161 MIM:616644; Vega:OTTHUMG00000019195
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERG1; ERG-1; UO-44; ITMAP1
Expression
Restricted expression toward pancreas (RPKM 310.9) See more
Orthologs

Genomic context

See CUZD1 in Genome Data Viewer
Location:
10q26.13
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (122832155..122846175, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (124591671..124605691, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene deleted in malignant brain tumors 1 pseudogene 1 Neighboring gene deleted in malignant brain tumors 1 protein Neighboring gene FAM24B-CUZD1 readthrough Neighboring gene family with sequence similarity 24 member B Neighboring gene chromosome 10 open reading frame 88 pseudogene Neighboring gene family with sequence similarity 24 member A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough FAM24B-CUZD1

Readthrough gene: FAM24B-CUZD1, Included gene: FAM24B

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
substrate-dependent cell migration, cell attachment to substrate NAS
Non-traceable Author Statement
more info
PubMed 
trypsinogen activation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
zymogen granule membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
CUB and zona pellucida-like domain-containing protein 1
Names
CUB and ZP domain-containing protein 1
estrogen regulated gene 1
transmembrane protein UO-44

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022034.5NP_071317.2  CUB and zona pellucida-like domain-containing protein 1 precursor

    See identical proteins and their annotated locations for NP_071317.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), also known as UO-44D, represents the longer transcript and encodes the supported protein.
    Source sequence(s)
    AL359747, AY260047
    Consensus CDS
    CCDS7631.1
    UniProtKB/Swiss-Prot
    Q86UP6
    Related
    ENSP00000376540.1, ENST00000392790.5
    Conserved Domains (4) summary
    smart00042
    Location:53143
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    smart00241
    Location:276519
    ZP; Zona pellucida (ZP) domain
    cd00041
    Location:154264
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam00100
    Location:400517
    Zona_pellucida; Zona pellucida-like domain

RNA

  1. NR_037912.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), also known as UO-44C, lacks an alternate exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL359747, AY260049
    Related
    ENST00000368901.5, OTTHUMT00000050830

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    122832155..122846175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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