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BOLA-DRA major histocompatibility complex, class II, DR alpha [ Bos taurus (domestic cattle) ]

Gene ID: 506214, updated on 5-Sep-2025
Gene symbol
BOLA-DRA
Gene description
major histocompatibility complex, class II, DR alpha
See related
BGD:BT10358; EnsemblRapid:ENSBTAG00070010923
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human all
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See BOLA-DRA in Genome Data Viewer
Location:
chromosome: 23
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (25838391..25843092, complement)

Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene DR-beta chain pseudogene Neighboring gene histocompatibility complex, class II, DR beta 2 Neighboring gene butyrophilin like 2 Neighboring gene butyrophilin family member

Genomic Sequence:
NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Short communication: Identification of allelic variation at the bovine DRA locus by polymerase chain reaction-single strand conformational polymorphism. Zhou H, et al. J Dairy Sci, 2007 Apr. PMID 17369234
  2. Molecular cloning and sequencing of a cattle DRA cDNA. Fraser DC, et al. Immunogenetics, 1994. PMID 8082897
  3. Cloning of cDNAs and the molecular evolution of a bovine MHC class II DRA gene. Aida Y, et al. Biochem Biophys Res Commun, 1994 Oct 14. PMID 7945359
  4. Structure of the BoLA-DRB3 gene and promoter. Russell GC, et al. Eur J Immunogenet, 2004 Jun. PMID 15182329
  5. The nucleotide sequence of the bovine MHC class II alpha genes: DRA, DOA, and DYA. van der Poel JJ, et al. Immunogenetics, 1990. PMID 2298463

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ALOX5AP, CPNE3, IL1R2, IL6, TLR2, TLR4, and THY1 were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows.
    Title: Greater expression of TLR2, TLR4, and IL6 due to negative energy balance is associated with lower expression of HLA-DRA and HLA-A in bovine blood neutrophils after intramammary mastitis challenge with Streptococcus uberis.
  2. Four unique SSCP patterns were detected among 384 cattle from New Zealand and sequence analysis revealed that these SSCP patterns represent 4 DRA alleles; and 3 single nucleotide polymorphisms were detected in exon 2
    Title: Short communication: Identification of allelic variation at the bovine DRA locus by polymerase chain reaction-single strand conformational polymorphism.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in antigen processing and presentation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of MHC class II protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
major histocompatibility complex, class II, DR alpha
Names
BoLA-DR-alpha
MHC class II antigen

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012677.1 → NP_001012695.1  major histocompatibility complex, class II, DR alpha precursor

    See identical proteins and their annotated locations for NP_001012695.1

    Status: PROVISIONAL

    Source sequence(s)
    BT021059
    UniProtKB/TrEMBL
    Q30309, Q3ZCL4, Q95111
    Related
    ENSBTAP00070014634.1, ENSBTAT00070024607.1
    Conserved Domains (3) summary
    cd05767
    Location:110 → 203
    IgC_MHC_II_alpha; Class II major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    pfam00993
    Location:29 → 105
    MHC_II_alpha; Class II histocompatibility antigen, alpha domain
    pfam16196
    Location:201 → 252
    C1-set_C; C1-set C-terminal domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    25838391..25843092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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