Format

Send to:

Choose Destination

UBQLN3 ubiquilin 3 [ Homo sapiens (human) ]

Gene ID: 50613, updated on 17-Jan-2022

Summary

Official Symbol
UBQLN3provided by HGNC
Official Full Name
ubiquilin 3provided by HGNC
Primary source
HGNC:HGNC:12510
See related
Ensembl:ENSG00000175520 MIM:605473
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TUP-1
Summary
This gene encodes a ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and are thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This gene is specifically expressed in the testis. It has been suggested that this gene may regulate cell-cycle progression during spermatogenesis, however, it has been shown that the ortholgous mouse gene is dispensable for embryonic development and spermatogenesis. [provided by RefSeq, Nov 2016]
Expression
Restricted expression toward testis (RPKM 82.9) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See UBQLN3 in Genome Data Viewer
Location:
11p15.4
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (5507300..5509957, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (5528530..5531187, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 51 subfamily B member 5 Neighboring gene olfactory receptor family 51 subfamily A member 10 pseudogene Neighboring gene olfactory receptor family 52 subfamily D member 1 Neighboring gene ubiquilin like Neighboring gene olfactomedin family member 5, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquilin-3
Names
testicular tissue protein Li 220

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347096.2NP_001334025.1  ubiquilin-3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA725499, BC036743, BF979648, BI828244, HM005533
    Consensus CDS
    CCDS7758.1
    UniProtKB/Swiss-Prot
    Q9H347
    UniProtKB/TrEMBL
    A0A140VJZ3
  2. NM_017481.4NP_059509.1  ubiquilin-3

    See identical proteins and their annotated locations for NP_059509.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA725499, BC036743, BF979648, HM005533
    Consensus CDS
    CCDS7758.1
    UniProtKB/Swiss-Prot
    Q9H347
    UniProtKB/TrEMBL
    A0A140VJZ3
    Related
    ENSP00000347997.2, ENST00000311659.5
    Conserved Domains (4) summary
    smart00213
    Location:2292
    UBQ; Ubiquitin homologues
    cd14399
    Location:615654
    UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
    cl00155
    Location:2292
    UBQ; Ubiquitin-like proteins
    cl19831
    Location:540645
    PilP; Pilus assembly protein, PilP

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    5507300..5509957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520145.3XP_011518447.1  ubiquilin-3 isoform X1

    Conserved Domains (4) summary
    smart00213
    Location:2292
    UBQ; Ubiquitin homologues
    cd14399
    Location:462501
    UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
    cl00155
    Location:2292
    UBQ; Ubiquitin-like proteins
    cl19831
    Location:387492
    PilP; Pilus assembly protein, PilP
Support Center