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PDGFA platelet derived growth factor subunit A [ Bos taurus (domestic cattle) ]

Gene ID: 505908, updated on 5-Sep-2025
Official Symbol
PDGFAprovided by VGNC
Official Full Name
platelet derived growth factor subunit Aprovided by VGNC
Primary source
VGNC:VGNC:32689
See related
EnsemblRapid:ENSBTAG00070014993
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See PDGFA in Genome Data Viewer
Location:
chromosome: 25
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 25 NC_037352.1 (42009812..42030408)

Chromosome 25 - NC_037352.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112444333 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit beta Neighboring gene uncharacterized LOC101904836 Neighboring gene forkhead box L3 Neighboring gene FAM20C golgi associated secretory pathway kinase

Genomic Sequence:
NC_037352.1 Chromosome 25 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables platelet-derived growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in platelet-derived growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
platelet-derived growth factor subunit A
Names
PDGF subunit A
platelet-derived growth factor A chain
platelet-derived growth factor alpha polypeptide

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001075231.1 → NP_001068699.1  platelet-derived growth factor subunit A precursor

    See identical proteins and their annotated locations for NP_001068699.1

    Status: PROVISIONAL

    Source sequence(s)
    BC105569
    UniProtKB/Swiss-Prot
    Q2KJ15
    Related
    ENSBTAP00070020096.1, ENSBTAT00070033915.1
    Conserved Domains (2) summary
    smart00141
    Location:94 → 179
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:21 → 95
    PDGF_N; Platelet-derived growth factor, N terminal region

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037352.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    42009812..42030408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059881190.1 → XP_059737173.1  platelet-derived growth factor subunit A isoform X1

    UniProtKB/TrEMBL
    A0AAA9T0M6
    Related
    ENSBTAP00070020134.1, ENSBTAT00070033963.1

  2. XM_059881192.1 → XP_059737175.1  platelet-derived growth factor subunit A isoform X3

    UniProtKB/TrEMBL
    A0AAA9S4T8, A0AAF6Z0H2
    Related
    ENSBTAP00070020122.1, ENSBTAT00070033948.1

  3. XM_024984705.2 → XP_024840473.1  platelet-derived growth factor subunit A isoform X4

    UniProtKB/TrEMBL
    A0AAF6Z0H2
    Conserved Domains (2) summary
    smart00141
    Location:94 → 179
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:21 → 95
    PDGF_N; Platelet-derived growth factor, N terminal region

  4. XM_024984702.2 → XP_024840470.1  platelet-derived growth factor subunit A isoform X2

    UniProtKB/Swiss-Prot
    Q2KJ15
    Conserved Domains (2) summary
    smart00141
    Location:94 → 179
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:21 → 95
    PDGF_N; Platelet-derived growth factor, N terminal region

  5. XM_024984701.2 → XP_024840469.1  platelet-derived growth factor subunit A isoform X2

    UniProtKB/Swiss-Prot
    Q2KJ15
    Conserved Domains (2) summary
    smart00141
    Location:94 → 179
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:21 → 95
    PDGF_N; Platelet-derived growth factor, N terminal region

  6. XM_059881191.1 → XP_059737174.1  platelet-derived growth factor subunit A isoform X2

    UniProtKB/Swiss-Prot
    Q2KJ15

  7. XM_024984703.2 → XP_024840471.1  platelet-derived growth factor subunit A isoform X4

    UniProtKB/TrEMBL
    A0AAF6Z0H2
    Conserved Domains (2) summary
    smart00141
    Location:94 → 179
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:21 → 95
    PDGF_N; Platelet-derived growth factor, N terminal region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2KJ15.1 GenPept UniProtKB/Swiss-Prot:Q2KJ15

Gene LinkOut

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