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Grem1 gremlin 1, DAN family BMP antagonist [ Rattus norvegicus (Norway rat) ]

Gene ID: 50566, updated on 21-Jul-2018

Summary

Official Symbol
Grem1provided by RGD
Official Full Name
gremlin 1, DAN family BMP antagonistprovided by RGD
Primary source
RGD:2359
See related
Ensembl:ENSRNOG00000026053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
drm; Cktsf1b1
Summary
protein may play a role in cellular growth control, viability and differentiation; high expression levels may induce apoptosis [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 82.9), Spleen (RPKM 18.7) and 4 other tissues See more
Orthologs

Genomic context

See Grem1 in Genome Data Viewer
Location:
3q35
Exon count:
2
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (105203309..105214989, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (111779965..111791645, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene formin 1 Neighboring gene mRNA turnover protein 4 homolog Neighboring gene twinfilin-2-like Neighboring gene similar to sorbitol dehydrogenase 1 Neighboring gene secretogranin V Neighboring gene Rho GTPase activating protein 11A

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
BMP binding ISO
Inferred from Sequence Orthology
more info
 
BMP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein tyrosine kinase activator activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
vascular endothelial growth factor receptor 2 binding IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor receptor 2 binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
activation of transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
apoptotic process IEP
Inferred from Expression Pattern
more info
PubMed 
branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cell-cell signaling IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
collagen fibril organization IEA
Inferred from Electronic Annotation
more info
 
collagen fibril organization ISO
Inferred from Sequence Orthology
more info
 
determination of dorsal identity IEA
Inferred from Electronic Annotation
more info
 
determination of dorsal identity ISO
Inferred from Sequence Orthology
more info
 
embryonic limb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
limb development ISO
Inferred from Sequence Orthology
more info
 
mesenchymal to epithelial transition involved in metanephros morphogenesis IEA
Inferred from Electronic Annotation
more info
 
mesenchymal to epithelial transition involved in metanephros morphogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of bone mineralization involved in bone maturation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of bone mineralization involved in bone maturation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of bone remodeling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of bone remodeling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of bone trabecula formation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of bone trabecula formation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of leukocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of monocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of osteoblast proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of osteoclast proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of osteoclast proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of pathway-restricted SMAD protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NIK/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor internalization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of telomerase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
proximal/distal pattern formation IEA
Inferred from Electronic Annotation
more info
 
proximal/distal pattern formation ISO
Inferred from Sequence Orthology
more info
 
regulation of epithelial to mesenchymal transition IEA
Inferred from Electronic Annotation
more info
 
regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
regulation of focal adhesion assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
NOT regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
NOT signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
ureteric bud formation IEA
Inferred from Electronic Annotation
more info
 
ureteric bud formation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cell surface ISO
Inferred from Sequence Orthology
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
gremlin-1
Names
cysteine knot superfamily 1, BMP antagonist 1
down-regulated in Mos-transformed cells protein
gremlin 1 homolog, cysteine knot superfamily

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019282.3NP_062155.1  gremlin-1 precursor

    See identical proteins and their annotated locations for NP_062155.1

    Status: VALIDATED

    Source sequence(s)
    AABR07053411, Y10019
    UniProtKB/Swiss-Prot
    O35793
    Related
    ENSRNOP00000035888.2, ENSRNOT00000037895.3
    Conserved Domains (1) summary
    pfam03045
    Location:76179
    DAN; DAN domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    105203309..105214989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    99483712..99495442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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