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Grem1 gremlin 1, DAN family BMP antagonist [ Rattus norvegicus (Norway rat) ]

Gene ID: 50566, updated on 12-Jan-2022

Summary

Official Symbol
Grem1provided by RGD
Official Full Name
gremlin 1, DAN family BMP antagonistprovided by RGD
Primary source
RGD:2359
See related
Ensembl:ENSRNOG00000026053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
drm; Cktsf1b1
Summary
Predicted to enable several functions, including BMP binding activity; protein homodimerization activity; and signaling receptor activator activity. Involved in several processes, including negative regulation of cell growth; negative regulation of monocyte chemotaxis; and positive regulation of angiogenesis. Acts upstream of or within negative regulation of osteoblast differentiation. Located in cell surface and extracellular space. Orthologous to human GREM1 (gremlin 1, DAN family BMP antagonist). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Kidney (RPKM 82.9), Spleen (RPKM 18.7) and 4 other tissues See more
Orthologs
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Genomic context

See Grem1 in Genome Data Viewer
Location:
3q35
Exon count:
2
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (100512317..100524001, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (105203309..105214989, complement)

Chromosome 3 - NC_051338.1Genomic Context describing neighboring genes Neighboring gene formin 1 Neighboring gene mRNA turnover protein 4 homolog Neighboring gene similar to sorbitol dehydrogenase 1 Neighboring gene secretogranin V Neighboring gene Rho GTPase activating protein 11A

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables BMP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables BMP binding ISO
Inferred from Sequence Orthology
more info
 
enables BMP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables receptor ligand activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane receptor protein tyrosine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables vascular endothelial growth factor receptor 2 binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in activation of transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in collagen fibril organization ISO
Inferred from Sequence Orthology
more info
 
involved_in determination of dorsal identity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in limb development ISO
Inferred from Sequence Orthology
more info
 
involved_in mesenchymal to epithelial transition involved in metanephros morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of bone mineralization involved in bone maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of bone remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of bone trabecula formation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of leukocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of monocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of osteoclast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proximal/distal pattern formation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in sequestering of BMP from receptor via BMP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in ureteric bud formation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
gremlin-1
Names
cysteine knot superfamily 1, BMP antagonist 1
down-regulated in Mos-transformed cells protein
gremlin 1 homolog, cysteine knot superfamily

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019282.3NP_062155.1  gremlin-1 precursor

    See identical proteins and their annotated locations for NP_062155.1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000118, Y10019
    UniProtKB/Swiss-Prot
    O35793
    Related
    ENSRNOP00000035888.2, ENSRNOT00000037895.4
    Conserved Domains (1) summary
    pfam03045
    Location:72179
    DAN; DAN domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051338.1 Reference mRatBN7.2 Primary Assembly

    Range
    100512317..100524001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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