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Gja5 gap junction protein, alpha 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 50563, updated on 30-Sep-2021

Summary

Official Symbol
Gja5provided by RGD
Official Full Name
gap junction protein, alpha 5provided by RGD
Primary source
RGD:2692
See related
EnsemblRapid:ENSRNOG00000017484
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cx40; Cxni
Summary
forms intercellular connoxin channels in gap junctions; mediates cell-cell communication [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 84.8), Heart (RPKM 24.7) and 6 other tissues See more
Orthologs
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Genomic context

See Gja5 in Genome Data Viewer
Location:
2q34
Exon count:
3
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (184602407..184621952)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (199162745..199184942)

Chromosome 2 - NC_051337.1Genomic Context describing neighboring genes Neighboring gene gap junction protein, alpha 8 Neighboring gene similar to Protein C14orf111 Neighboring gene tubulin alpha-1C chain-like Neighboring gene uncharacterized LOC102553665

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within AV node cell to bundle of His cell communication ISO
Inferred from Sequence Orthology
more info
 
involved_in AV node cell to bundle of His cell communication by electrical coupling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within SA node cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in artery morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in atrial cardiac muscle cell to AV node cell communication by electrical coupling ISO
Inferred from Sequence Orthology
more info
 
involved_in atrial septum development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within atrial septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within atrial ventricular junction remodeling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood vessel development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood vessel diameter maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in bundle of His cell to Purkinje myocyte communication by electrical coupling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac conduction system development ISO
Inferred from Sequence Orthology
more info
 
involved_in cell communication by chemical coupling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell communication by electrical coupling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell communication by electrical coupling involved in cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
involved_in cell communication by electrical coupling involved in cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell communication involved in cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to platelet-derived growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic heart tube development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelium development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within foramen ovale closure ISO
Inferred from Sequence Orthology
more info
 
involved_in gap junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in heart development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in mitral valve development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glomerular filtration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell communication by chemical coupling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pulmonary valve formation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of AV node cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Purkinje myocyte action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of atrial cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of atrial cardiac muscle cell membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of atrial cardiac muscle cell membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of bundle of His cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell communication by electrical coupling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of membrane depolarization during cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of renin secretion into blood stream ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of regulation of ventricular cardiac muscle cell membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of ventricular cardiac muscle cell membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of regulation of ventricular cardiac muscle cell membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of ventricular cardiac muscle cell membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within renal system process involved in regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within septum primum development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal system development ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in vasodilation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasomotion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ventricular cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular septum development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ventricular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell projection IDA
Inferred from Direct Assay
more info
PubMed 
part_of connexin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of connexin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of connexin complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of connexin complex ISO
Inferred from Sequence Orthology
more info
 
located_in gap junction ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intercalated disc ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
gap junction alpha-5 protein
Names
connexin 40
connexin i
gap junction membrane channel protein alpha 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019280.1NP_062153.1  gap junction alpha-5 protein

    See identical proteins and their annotated locations for NP_062153.1

    Status: PROVISIONAL

    Source sequence(s)
    AF021806
    UniProtKB/Swiss-Prot
    P28234
    Related
    ENSRNOP00000076921.1, ENSRNOT00000108116.1
    Conserved Domains (2) summary
    pfam00029
    Location:3230
    Connexin
    pfam16791
    Location:255356
    Connexin40_C; Connexin 40 C-terminal domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051337.1 Reference mRatBN7.2 Primary Assembly

    Range
    184602407..184621952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102970.1XP_038958898.1  gap junction alpha-5 protein isoform X1

    Related
    ENSRNOP00000023488.3, ENSRNOT00000023488.7
    Conserved Domains (2) summary
    pfam00029
    Location:3230
    Connexin
    pfam16791
    Location:255356
    Connexin40_C; Connexin 40 C-terminal domain
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