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Mfap5 microfibrillar associated protein 5 [ Mus musculus (house mouse) ]

Gene ID: 50530, updated on 5-Mar-2024

Summary

Official Symbol
Mfap5provided by MGI
Official Full Name
microfibrillar associated protein 5provided by MGI
Primary source
MGI:MGI:1354387
See related
Ensembl:ENSMUSG00000030116 AllianceGenome:MGI:1354387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MAGP-2; MFAP-5
Summary
Predicted to enable extracellular matrix constituent conferring elasticity. Involved in definitive hemopoiesis. Acts upstream of or within supramolecular fiber organization. Located in extracellular matrix. Is expressed in aorta; bladder; esophagus; male reproductive system; and skeletal musculature. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human MFAP5 (microfibril associated protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 54.4), mammary gland adult (RPKM 48.6) and 10 other tissues See more
Orthologs
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Genomic context

See Mfap5 in Genome Data Viewer
Location:
6 F1; 6 57.61 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (122490543..122506249)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (122513584..122529290)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene STARR-seq mESC enhancer starr_17224 Neighboring gene ribosomal modification protein rimK-like family member B Neighboring gene ribosomal protein S27A, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_17225 Neighboring gene STARR-positive B cell enhancer ABC_E10409 Neighboring gene STARR-positive B cell enhancer ABC_E1070 Neighboring gene STARR-positive B cell enhancer ABC_E9100 Neighboring gene STARR-positive B cell enhancer mm9_chr6:122484210-122484511 Neighboring gene STARR-positive B cell enhancer ABC_E11336 Neighboring gene STARR-positive B cell enhancer ABC_E3677 Neighboring gene STARR-positive B cell enhancer ABC_E3678 Neighboring gene activation-induced cytidine deaminase Neighboring gene voltage-dependent anion channel 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
microfibrillar-associated protein 5
Names
microfibril-associated glycoprotein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347434.1NP_001334363.1  microfibrillar-associated protein 5 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AC155946
    Consensus CDS
    CCDS85155.1
    UniProtKB/TrEMBL
    D3Z4D7, F8WJ99
    Related
    ENSMUSP00000032210.9, ENSMUST00000032210.14
  2. NM_015776.3NP_056591.1  microfibrillar-associated protein 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_056591.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC155946
    Consensus CDS
    CCDS20496.1
    UniProtKB/Swiss-Prot
    Q9QZJ6
    UniProtKB/TrEMBL
    D3Z4D7
    Related
    ENSMUSP00000122863.2, ENSMUST00000148517.8
    Conserved Domains (1) summary
    pfam05507
    Location:35129
    MAGP; Microfibril-associated glycoprotein (MAGP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    122490543..122506249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)