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Lats2 large tumor suppressor 2 [ Mus musculus (house mouse) ]

Gene ID: 50523, updated on 29-Oct-2019

Summary

Official Symbol
Lats2provided by MGI
Official Full Name
large tumor suppressor 2provided by MGI
Primary source
MGI:MGI:1354386
See related
Ensembl:ENSMUSG00000021959 Ensembl:ENSMUSG00000114942
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AV277261; AW228608; 4932411G09Rik
Expression
Ubiquitous expression in testis adult (RPKM 26.6), lung adult (RPKM 25.8) and 28 other tissues See more
Orthologs

Genomic context

See Lats2 in Genome Data Viewer
Location:
14; 14 C3
Exon count:
9
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (57689662..57746212, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (58308499..58364960, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene EEF1A alpha lysine methyltransferase 1 Neighboring gene RIKEN cDNA 1700039M10 gene Neighboring gene exportin 4 Neighboring gene predicted gene, 26440 Neighboring gene predicted gene, 52140 Neighboring gene microRNA 3077 Neighboring gene Sin3-associated polypeptide 18 Neighboring gene spindle and kinetochore associated complex subunit 3 Neighboring gene mitochondrial ribosomal protein L57

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular protein localization IDA
Inferred from Direct Assay
more info
PubMed 
cellular protein localization IGI
Inferred from Genetic Interaction
more info
PubMed 
hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hippo signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
hippo signaling ISO
Inferred from Sequence Orthology
more info
 
hormone-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
inner cell mass cell fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
inner cell mass cellular morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
keratinocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of organ growth IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase LATS2
Names
kinase phosphorylated during mitosis protein
large tumor suppressor homolog 2
lats2
serine/threonine-protein kinase kpm
NP_056586.2
NP_700431.1
XP_006519287.1
XP_006519288.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015771.2NP_056586.2  serine/threonine-protein kinase LATS2 isoform 1

    See identical proteins and their annotated locations for NP_056586.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    BC053028, BU705730
    Consensus CDS
    CCDS27158.1
    UniProtKB/Swiss-Prot
    Q7TSJ6
    Related
    ENSMUSP00000022531.7, ENSMUST00000022531.13
    Conserved Domains (3) summary
    smart00220
    Location:626931
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14398
    Location:100140
    UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2
    cl21453
    Location:6241004
    PKc_like; Protein Kinases, catalytic domain
  2. NM_153382.1NP_700431.1  serine/threonine-protein kinase LATS2 isoform 2

    See identical proteins and their annotated locations for NP_700431.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) lacks the first exon, most of the 3' coding region and uses a different terminal exon compared to variant A. The resulting protein (isoform 2, also called LATS2B) is much shorter and has a distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC154504, BF147719
    Consensus CDS
    CCDS49508.1
    UniProtKB/TrEMBL
    Q8VHE2
    Related
    ENSMUSP00000077130.6, ENSMUST00000077981.6

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p6 C57BL/6J

    Range
    57689662..57746212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519224.4XP_006519287.1  serine/threonine-protein kinase LATS2 isoform X1

    Related
    ENSMUSP00000133680.1, ENSMUST00000174694.7
    Conserved Domains (3) summary
    smart00220
    Location:626847
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14398
    Location:100140
    UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2
    cl21453
    Location:624847
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006519225.3XP_006519288.1  serine/threonine-protein kinase LATS2 isoform X2

    See identical proteins and their annotated locations for XP_006519288.1

    UniProtKB/TrEMBL
    Q8VHE2
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