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E2f6 E2F transcription factor 6 [ Mus musculus (house mouse) ]

Gene ID: 50496, updated on 1-Oct-2024

Summary

Official Symbol
E2f6provided by MGI
Official Full Name
E2F transcription factor 6provided by MGI
Primary source
MGI:MGI:1354159
See related
Ensembl:ENSMUSG00000057469 AllianceGenome:MGI:1354159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EMA; E2F6a; E2F6b
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Acts upstream of or within regulation of transcription involved in G1/S transition of mitotic cell cycle. Predicted to be located in nucleoplasm. Predicted to be part of MLL1 complex and RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Orthologous to human E2F6 (E2F transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 10.4), heart adult (RPKM 9.5) and 28 other tissues See more
Orthologs
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Genomic context

See E2f6 in Genome Data Viewer
Location:
12 A1.1; 12 8.04 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (16860932..16876753)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (16810909..16826752)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31645 Neighboring gene neurotensin receptor 2 Neighboring gene gene regulated by estrogen in breast cancer protein Neighboring gene STARR-seq mESC enhancer starr_31647 Neighboring gene predicted gene, 36495 Neighboring gene STARR-seq mESC enhancer starr_31650 Neighboring gene Rho-associated coiled-coil containing protein kinase 2 Neighboring gene predicted gene, 22303

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of DNA replication factor A complex IC
Inferred by Curator
more info
PubMed 
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of MLL1 complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of RNA polymerase II transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transcription factor E2F6
Names
E2F-6
E2F-binding site-modulating activity protein
transcriptional repressor E2F6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033270.2NP_150373.2  transcription factor E2F6

    See identical proteins and their annotated locations for NP_150373.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AI851823, BC037656, BY739130
    Consensus CDS
    CCDS36409.1
    UniProtKB/Swiss-Prot
    O54917, Q8K456
    UniProtKB/TrEMBL
    Q8VHT5
    Related
    ENSMUSP00000020908.8, ENSMUST00000020908.9
    Conserved Domains (2) summary
    cd14660
    Location:139239
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:65128
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

RNA

  1. NR_027677.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an additional, out-of-frame, exon at the 5' end compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI851823, AK146792, CJ075693
    Related
    ENSMUST00000221541.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    16860932..16876753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515147.2XP_006515210.1  transcription factor E2F6 isoform X1

    See identical proteins and their annotated locations for XP_006515210.1

    UniProtKB/TrEMBL
    Q8VHT4, Q8VHT5
    Conserved Domains (2) summary
    cd14660
    Location:104204
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:2993
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
  2. XM_036157521.1XP_036013414.1  transcription factor E2F6 isoform X2

    UniProtKB/TrEMBL
    Q8VHT5
    Conserved Domains (2) summary
    cd14660
    Location:87187
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:1376
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
  3. XM_006515148.3XP_006515211.1  transcription factor E2F6 isoform X1

    See identical proteins and their annotated locations for XP_006515211.1

    UniProtKB/TrEMBL
    Q8VHT4, Q8VHT5
    Conserved Domains (2) summary
    cd14660
    Location:104204
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:2993
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
  4. XM_006515149.5XP_006515212.1  transcription factor E2F6 isoform X2

    UniProtKB/TrEMBL
    Q8VHT5
    Conserved Domains (2) summary
    cd14660
    Location:87187
    E2F_DD; Dimerization domain of E2F transcription factors
    pfam02319
    Location:1376
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain