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MINK1 misshapen like kinase 1 [ Homo sapiens (human) ]

Gene ID: 50488, updated on 3-Jun-2018
Official Symbol
MINK1provided by HGNC
Official Full Name
misshapen like kinase 1provided by HGNC
Primary source
HGNC:HGNC:17565
See related
Ensembl:ENSG00000141503 MIM:609426; Vega:OTTHUMG00000177932
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B55; ZC3; MINK; YSK2; MAP4K6
Summary
This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in skin (RPKM 48.7), brain (RPKM 31.3) and 25 other tissues See more
Orthologs
See MINK1 in Genome Data Viewer
Location:
17p13.2
Exon count:
35
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (4833340..4898061)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4736635..4801356)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene proteasome subunit beta 6 Neighboring gene phospholipase D2 Neighboring gene ATPase H+ transporting V0 subunit c pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 784, pseudogene Neighboring gene chromosome 17 open reading frame 107 Neighboring gene cholinergic receptor nicotinic epsilon subunit Neighboring gene glycoprotein Ib platelet subunit alpha

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystem (from WikiPathways)
    Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystemThe hepatic ANGPTL8 (Angiopoietin Like Protein 8) regulatory pathway represents an up-to-date curated interactive pathway for all of the interactions from the known regulators of ANGPTL8 and updated ...
  • Cellular Senescence, organism-specific biosystem (from REACTOME)
    Cellular Senescence, organism-specific biosystemCellular senescence involves irreversible growth arrest accompanied by phenotypic changes such as enlarged morphology, reorganization of chromatin through formation of senescence-associated heterochr...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
  • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Oxidative Stress Induced Senescence, organism-specific biosystem (from REACTOME)
    Oxidative Stress Induced Senescence, organism-specific biosystemOxidative stress, caused by increased concentration of reactive oxygen species (ROS) in the cell, can happen as a consequence of mitochondrial dysfunction induced by the oncogenic RAS (Moiseeva et al...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC21111

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
JNK cascade TAS
Traceable Author Statement
more info
PubMed 
MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton reorganization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of MAPKKK activity IEA
Inferred from Electronic Annotation
more info
 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemical synaptic transmission ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT microvillus assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of p38MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of AMPA receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
axon IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
misshapen-like kinase 1
Names
GCK family kinase MINK
MAPK/ERK kinase kinase kinase 6
MEK kinase kinase 6
MEKKK 6
misshapen/NIK-related kinase
mitogen-activated protein kinase kinase kinase kinase 6
NP_001020108.1
NP_001308165.1
NP_056531.1
NP_722549.2
NP_733763.1
XP_006721594.1
XP_006721595.1
XP_006721599.1
XP_011522208.1
XP_016880193.1
XP_016880194.1
XP_016880195.1
XP_016880196.1
XP_016880197.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028005.1 RefSeqGene

    Range
    5001..69722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001024937.3NP_001020108.1  misshapen-like kinase 1 isoform 4

    See identical proteins and their annotated locations for NP_001020108.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and contains another alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini and is longer compared to isoform 1.
    Source sequence(s)
    AB041926, AL157418, AY775058, DA653105
    Consensus CDS
    CCDS45590.1
    UniProtKB/Swiss-Prot
    Q8N4C8
    Related
    ENSP00000406487.3, OTTHUMP00000258117, ENST00000453408.7, OTTHUMT00000439805
    Conserved Domains (3) summary
    smart00036
    Location:9941292
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  2. NM_001321236.1NP_001308165.1  misshapen-like kinase 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AB041926, AL157418, BC094686, DA653105
    UniProtKB/Swiss-Prot
    Q8N4C8
    Conserved Domains (3) summary
    smart00036
    Location:9221220
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:11234
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1234
    PKc_like; Protein Kinases, catalytic domain
  3. NM_015716.4NP_056531.1  misshapen-like kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_056531.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shortest isoform (1).
    Source sequence(s)
    AB035698, AB041926, AL157418, DA653105
    UniProtKB/Swiss-Prot
    Q8N4C8
    Conserved Domains (3) summary
    smart00036
    Location:9771275
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  4. NM_153827.4NP_722549.2  misshapen-like kinase 1 isoform 3

    See identical proteins and their annotated locations for NP_722549.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an additional in-frame exon, compared to variant 1, resulting in the longest isoform (3) which has a unique internal segment, compared to isoform 1.
    Source sequence(s)
    AB035698, AB041926, AL157418, BC034673, DA653105
    Consensus CDS
    CCDS45588.1
    UniProtKB/Swiss-Prot
    Q8N4C8
    Related
    ENSP00000347427.6, OTTHUMP00000258114, ENST00000355280.10, OTTHUMT00000439801
    Conserved Domains (3) summary
    smart00036
    Location:10141312
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  5. NM_170663.4NP_733763.1  misshapen-like kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_733763.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an additional in-frame exon, compared to variant 1, resulting in a longer isoform (2) that has a unique internal segment, compared to isoform 1.
    Source sequence(s)
    AB041926, AL157418, DA653105
    Consensus CDS
    CCDS45589.1
    UniProtKB/Swiss-Prot
    Q8N4C8
    Related
    ENSP00000269296.7, OTTHUMP00000258115, ENST00000347992.11, OTTHUMT00000439803
    Conserved Domains (3) summary
    smart00036
    Location:9851283
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    4833340..4898061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721531.2XP_006721594.1  misshapen-like kinase 1 isoform X1

    Conserved Domains (3) summary
    smart00036
    Location:10431341
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  2. XM_006721532.2XP_006721595.1  misshapen-like kinase 1 isoform X2

    Conserved Domains (3) summary
    smart00036
    Location:10421340
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  3. XM_006721536.2XP_006721599.1  misshapen-like kinase 1 isoform X6

    Conserved Domains (3) summary
    smart00036
    Location:10061304
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  4. XM_017024706.1XP_016880195.1  misshapen-like kinase 1 isoform X7

  5. XM_017024705.1XP_016880194.1  misshapen-like kinase 1 isoform X4

  6. XM_017024704.1XP_016880193.1  misshapen-like kinase 1 isoform X3

  7. XM_011523906.1XP_011522208.1  misshapen-like kinase 1 isoform X5

    Conserved Domains (3) summary
    smart00036
    Location:10111309
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06636
    Location:8289
    STKc_MAP4K4_6_N; N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6
  8. XM_017024707.2XP_016880196.1  misshapen-like kinase 1 isoform X8

  9. XM_017024708.1XP_016880197.1  misshapen-like kinase 1 isoform X9

RNA

  1. XR_001752522.2 RNA Sequence

    Related
    ENST00000574453.5
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