DKK1 dickkopf WNT signaling pathway inhibitor 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: DKK1provided by VGNC
Official Full Name: dickkopf WNT signaling pathway inhibitor 1provided by VGNC
Primary source: VGNC:VGNC:28079
See related: BGD:BT15574; EnsemblRapid:ENSBTAG00070021152
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 26

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	26	NC_037353.1 (6846855..6849305, complement)

Chromosome 26 - NC_037353.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037353.1 Chromosome 26 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The decreased expression of Dkk-1 in somatic cell nuclear transfer cotyledons that are prone to abnormal placentation suggests a role in cotyledon formation but the mechanism and regulatory control is yet to be revealed[DICKKOPF-1]
Title: Dickkopf-1 expression during early bovine placentation and its down-regulation in somatic cell nuclear transfer (SCNT) pregnancies.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables co-receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables receptor antagonist activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: dickkopf-related protein 1

Names: dickkopf homolog 1; dickkopf-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.