NPY neuropeptide Y [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: NPYprovided by VGNC
Official Full Name: neuropeptide Yprovided by VGNC
Primary source: VGNC:VGNC:32222
See related: BGD:BT10657; EnsemblRapid:ENSBTAG00070016219
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	4	NC_037331.1 (71616855..71641810, complement)

Chromosome 4 - NC_037331.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin-NPY and insulin signaling pathways.
Title: Gene expression profiling of hormonal regulation related to the residual feed intake of Holstein cattle.
Data indicate that increased body weight gain during juvenile development accelerates sexual maturation in heifers, coincident with reciprocal changes in circulating concentrations of leptin and hypothalamic neuropeptide Y (NPY) release.
Title: Reciprocal changes in leptin and NPY during nutritional acceleration of puberty in heifers.
There is a strong association between putative favorable allelic variants (SNP) of neuropeptide Y, leptin, and IGF-1 genes, and residual feed intake, when animals were grazing on a high-quality, high-availability pasture.
Title: Association of SNP of neuropeptide Y, leptin, and IGF-1 genes with residual feed intake in confinement and under grazing condition in Angus cattle.
The NPY SNP (NPY1) was associated with the prevalence of the animal being in calf 100 d after calving and 305-d milk yield in the first lactation.
Title: Evidence that leptin genotype is associated with fertility, growth, and milk production in Holstein cows.
NPY tended to increase serum growth hormone, which appeared to be a consequence of increased pulse amplitude. Infusion of NPY also increased CSF growth hormone-releasing hormone.
Title: Dynamics of GHRH in third-ventricle cerebrospinal fluid of cattle: relationship with serum concentrations of GH and responses to appetite-regulating peptides.
Data show that PKA and PKC pathways are involved in the differential regulation of production of the neuropeptides (Met)enkephalin, galanin, somatostatin, NPY, and VIP.
Title: Differential activation of enkephalin, galanin, somatostatin, NPY, and VIP neuropeptide production by stimulators of protein kinases A and C in neuroendocrine chromaffin cells.
The effect of single nucleotide polymorphisms in 6 genes and their associations with production factors in beef cattle are reported.
Title: Polymorphisms and haplotypes in the bovine neuropeptide Y, growth hormone receptor, ghrelin, insulin-like growth factor 2, and uncoupling proteins 2 and 3 genes and their associations with measures of growth, performance, feed efficiency, and carcass merit in beef cattle.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables neuropeptide Y receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables neuropeptide hormone activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in feeding behavior	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: pro-neuropeptide Y

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014845.3 → NP_001014845.1 pro-neuropeptide Y precursor

See identical proteins and their annotated locations for NP_001014845.1

Status: PROVISIONAL

Source sequence(s)

BC133432

UniProtKB/Swiss-Prot

A2VDW2, Q6RUW3

UniProtKB/TrEMBL

A0AAF6YM98, B5M4A4

Conserved Domains (1) summary

smart00309
Location:29 → 64

PAH; Pancreatic hormones / neuropeptide F / peptide YY family