ak7b adenylate kinase 7b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ak7bprovided by ZNC
Official Full Name: adenylate kinase 7bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050309-170
See related: Ensembl:ENSDARG00000017023 AllianceGenome:ZFIN:ZDB-GENE-050309-170
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7150989; zgc:165635
Summary: Predicted to enable adenylate kinase activity; cytidylate kinase activity; and nucleoside diphosphate kinase activity. Predicted to be involved in nucleoside diphosphate phosphorylation and nucleoside triphosphate biosynthetic process. Predicted to act upstream of or within nucleobase-containing compound metabolic process and phosphorylation. Predicted to be active in cytoplasm. Is expressed in nervous system; neural tube; and pronephric duct. Human ortholog(s) of this gene implicated in spermatogenic failure 27. Orthologous to human AK7 (adenylate kinase 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (18877918..18888959, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (18858082..18869123, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate kinase activity	IEA Inferred from Electronic Annotation more info
enables cytidylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleobase-containing compound kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: adenylate kinase 7

NP_001103168.2

EC 2.7.4.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109698.2 → NP_001103168.2 adenylate kinase 7

Status: VALIDATED

Source sequence(s)

CU571402

UniProtKB/TrEMBL

A0A8M1NEC6, F1QF80

Related

ENSDARP00000074479.4, ENSDART00000080029.6

Conserved Domains (5) summary

COG0451
Location:129 → 286

WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]

COG0563
Location:363 → 583

Adk; Adenylate kinase or related kinase [Nucleotide transport and metabolism]

cd01428
Location:363 → 556

ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

pfam05186
Location:656 → 697

Dpy-30; Dpy-30 motif

cl21454
Location:212 → 286

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins