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DPRX divergent-paired related homeobox [ Homo sapiens (human) ]

Gene ID: 503834, updated on 23-Nov-2021

Summary

Official Symbol
DPRXprovided by HGNC
Official Full Name
divergent-paired related homeoboxprovided by HGNC
Primary source
HGNC:HGNC:32166
See related
Ensembl:ENSG00000204595 MIM:611165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the DPRX homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple, related processed pseudogenes have been found which are thought to reflect expression of this gene in the germ line or embryonic cells. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See DPRX in Genome Data Viewer
Location:
19q13.42
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (53601114..53637057)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54135310..54140263)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 813 Neighboring gene ribosomal protein L39 pseudogene 37 Neighboring gene vomeronasal 1 receptor 103 pseudogene Neighboring gene zinc finger protein 331 Neighboring gene solute carrier family 7 member 3 pseudogene Neighboring gene solute carrier family 7 member 3 pseudogene Neighboring gene oligosaccharyltransferase complex subunit pseudogene 3 Neighboring gene RNA, 7SL, cytoplasmic 317, pseudogene Neighboring gene uncharacterized LOC107985342 Neighboring gene nuclear RNA export factor 3 pseudogene Neighboring gene RNA, U6 small nuclear 698, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
divergent paired-related homeobox

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012728.2NP_001012746.1  divergent paired-related homeobox

    See identical proteins and their annotated locations for NP_001012746.1

    Status: VALIDATED

    Source sequence(s)
    AC011487
    Consensus CDS
    CCDS33103.1
    UniProtKB/Swiss-Prot
    A6NFQ7
    Related
    ENSP00000365838.1, ENST00000376650.1
    Conserved Domains (1) summary
    pfam00046
    Location:1972
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    53601114..53637057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527011.3XP_011525313.1  divergent paired-related homeobox isoform X1

    See identical proteins and their annotated locations for XP_011525313.1

    UniProtKB/Swiss-Prot
    A6NFQ7
    Conserved Domains (1) summary
    pfam00046
    Location:1972
    Homeobox; Homeobox domain
  2. XM_011527012.2XP_011525314.1  divergent paired-related homeobox isoform X1

    See identical proteins and their annotated locations for XP_011525314.1

    UniProtKB/Swiss-Prot
    A6NFQ7
    Conserved Domains (1) summary
    pfam00046
    Location:1972
    Homeobox; Homeobox domain
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