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FLT1 fms related receptor tyrosine kinase 1 [ Bos taurus (domestic cattle) ]

Gene ID: 503620, updated on 30-Jan-2025
Official Symbol
FLT1provided by VGNC
Official Full Name
fms related receptor tyrosine kinase 1provided by VGNC
Primary source
VGNC:VGNC:29041
See related
BGD:BT12183; EnsemblRapid:ENSBTAG00070008056
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
VEGFR1
Orthologs
human mouse all
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See FLT1 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 12 NC_037339.1 (31624080..31829381)

Chromosome 12 - NC_037339.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104973568 Neighboring gene uncharacterized LOC132346762 Neighboring gene microRNA mir-2300a Neighboring gene microRNA mir-2300b Neighboring gene poly(A) specific ribonuclease subunit PAN3 Neighboring gene centromere-associated protein E-like Neighboring gene fms related receptor tyrosine kinase 3 Neighboring gene microRNA mir-2285o-2

Genomic Sequence:
NC_037339.1 Chromosome 12 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. VEGF receptor-1 involvement in pericyte loss induced by Escherichia coli in an in vitro model of blood brain barrier. Salmeri M, et al. Cell Microbiol, 2013 Aug. PMID 23421875
  2. Vascular Endothelial Growth Factor A and VEGFR-1 Change during Preimplantation in Heifers. Chiumia D, et al. Int J Mol Sci, 2020 Jan 15. PMID 31952188, Free PMC Article
  3. Transforming growth factor beta 1 down-regulates vascular endothelial growth factor receptor 2/flk-1 expression in vascular endothelial cells. Mandriota SJ, et al. J Biol Chem, 1996 May 10. PMID 8626709
  4. Polymorphisms of RDH16 and VEGFR1 influence M. trapezius steatosis in Japanese Black carcass. Ishida T, et al. Anim Sci J, 2017 Aug. PMID 27878895
  5. Reduction in the mRNA expression of sVEGFR1 and sVEGFR2 is associated with the selection of dominant follicle in cows. Ortega Serrano PV, et al. Reprod Domest Anim, 2016 Dec. PMID 27650571

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Vascular Endothelial Growth Factor A and VEGFR-1 Change during Preimplantation in Heifers.
    Title: Vascular Endothelial Growth Factor A and VEGFR-1 Change during Preimplantation in Heifers.
  2. Evidence of an altered expression of VEGFA-164, VEGFA-164b and VEGFR2 during the formation of persistent follicles and cysts in cows.
    Title: Contribution of the VEGF system to the follicular persistence associated with bovine cystic ovaries.
  3. There is a possibility that steatosis can be suppressed by the CC genotype in VEGFR1.
    Title: Polymorphisms of RDH16 and VEGFR1 influence M. trapezius steatosis in Japanese Black carcass.
  4. These results suggest that non-dominant follicles maintain a greater concentration of the mRNA expression of both membrane and soluble VEGF receptors; but follicular dominance is related to a reduction in the mRNA expression of sVEGFR1 and sVEGFR2.
    Title: Reduction in the mRNA expression of sVEGFR1 and sVEGFR2 is associated with the selection of dominant follicle in cows.
  5. VEGFR-1 negatively regulates primary bovine retinal pericytes survival, and its blockade protects the blood-brain barrier integrity.
    Title: VEGF receptor-1 involvement in pericyte loss induced by Escherichia coli in an in vitro model of blood brain barrier.
  6. The changes of sVEGFR-1 and sVEGFR-2 with the age of the bovine dominant follicle indicate a physiological role in its growth and atresia.
    Title: Identification of soluble forms of vascular endothelial growth factor receptors, sVEGFR-1 and sVEGFR-2, in bovine dominant follicles.
  7. gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1
    Title: γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1.
  8. VEGFR1 mRNA expression was lower at estrus and at the early I and early II luteal stages than at the other stages, whereas VEGFR1 protein expression did not change significantly throughout the estrous cycle (P<0.05)
    Title: Expression of VEGF and its receptors in the bovine endometrium throughout the estrous cycle: effects of VEGF on prostaglandin production in endometrial cells.
  9. Alterations in the expression of VEGF-A and bFGF systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
    Title: Somatic cell nuclear transfer is associated with altered expression of angiogenic factor systems in bovine placentomes at term.
  10. inhibition of VEGFR-1 results in decrease in number of capillary connections indicating VEGFR-1 ligands promote branching angiogenesis.
    Title: Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells.
Submit: New GeneRIF Correction See all GeneRIFs (13)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables vascular endothelial growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
vascular endothelial growth factor receptor 1
Names
VEGF-receptor
flt-receptor
fms related tyrosine kinase 1
soluble VEGF receptor 1
vascular endothelial growth factor 1
vascular endothelial growth factor/vascular permeability factor receptor
NP_001178061.2
XP_015329239.1
XP_024855553.1
XP_024855554.1
XP_059747951.1
XP_059747952.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191132.4 → NP_001178061.2  vascular endothelial growth factor receptor 1 precursor

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000012
    UniProtKB/TrEMBL
    F1MDD9
    Related
    ENSBTAP00070010622.1, ENSBTAT00070018168.1
    Conserved Domains (5) summary
    smart00410
    Location:570 → 641
    IG_like; Immunoglobulin like
    pfam07679
    Location:662 → 749
    I-set; Immunoglobulin I-set domain
    pfam13927
    Location:436 → 540
    Ig_3; Immunoglobulin domain
    cl11960
    Location:354 → 425
    Ig; Immunoglobulin domain
    cl21453
    Location:820 → 1158
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037339.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    31624080..31829381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015473753.2 → XP_015329239.1  vascular endothelial growth factor receptor 1 isoform X4

    UniProtKB/TrEMBL
    A0A3Q1MF20
    Related
    ENSBTAP00070010582.1, ENSBTAT00070018109.1
    Conserved Domains (4) summary
    smart00408
    Location:700 → 771
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:368 → 459
    IG_like; Immunoglobulin like
    pfam13895
    Location:277 → 354
    Ig_2; Immunoglobulin domain
    cl11960
    Location:484 → 555
    Ig; Immunoglobulin domain

  2. XM_024999786.2 → XP_024855554.1  vascular endothelial growth factor receptor 1 isoform X5

    UniProtKB/TrEMBL
    A0A3Q1MF20
    Conserved Domains (4) summary
    smart00410
    Location:700 → 771
    IG_like; Immunoglobulin like
    pfam13927
    Location:558 → 670
    Ig_3; Immunoglobulin domain
    cl11960
    Location:484 → 555
    Ig; Immunoglobulin domain
    cl28434
    Location:792 → 836
    I-set; Immunoglobulin I-set domain

  3. XM_024999785.2 → XP_024855553.1  vascular endothelial growth factor receptor 1 isoform X3

    UniProtKB/TrEMBL
    A0AAA9TV30
    Conserved Domains (4) summary
    smart00410
    Location:700 → 771
    IG_like; Immunoglobulin like
    pfam13927
    Location:558 → 670
    Ig_3; Immunoglobulin domain
    cl11960
    Location:484 → 555
    Ig; Immunoglobulin domain
    cl28434
    Location:792 → 836
    I-set; Immunoglobulin I-set domain

  4. XM_059891969.1 → XP_059747952.1  vascular endothelial growth factor receptor 1 isoform X2

    UniProtKB/TrEMBL
    A0AAA9RZ35

  5. XM_059891968.1 → XP_059747951.1  vascular endothelial growth factor receptor 1 isoform X1

    UniProtKB/TrEMBL
    F1MDD9
Nucleotide Protein Strain
Heading Accession and Version

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