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DEFB107B defensin beta 107B [ Homo sapiens (human) ]

Gene ID: 503614, updated on 3-Sep-2017
Official Symbol
DEFB107Bprovided by HGNC
Official Full Name
defensin beta 107Bprovided by HGNC
Primary source
See related
Ensembl:ENSG00000198129 Vega:OTTHUMG00000149987
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 107, DEFB107A and DEFB107B, in tail-to-tail orientation. This gene, DEFB107B, represents the more telomeric copy. [provided by RefSeq, Oct 2014]
Low expression observed in reference dataset See more
Exon count:
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (7495846..7509311)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (7353368..7366833)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene defensin beta 106B Neighboring gene defensin beta 105B Neighboring gene uncharacterized LOC105377801 Neighboring gene proline-rich protein 23D1-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Antimicrobial peptides, organism-specific biosystem (from REACTOME)
    Antimicrobial peptides, organism-specific biosystemAntimicrobial peptides (AMPs) are small molecular weight proteins with broad spectrum of antimicrobial activity against bacteria, viruses, and fungi (Zasloff M 2002; Radek K & Gallo R 2007). The majo...
  • Beta defensins, organism-specific biosystem (from REACTOME)
    Beta defensins, organism-specific biosystemHumans have 38 beta-defensin genes plus 9-10 pseudogenes (details available on the HGNC website at Many beta-defensins are encoded by recently duplicated ...
  • Defensins, organism-specific biosystem (from REACTOME)
    Defensins, organism-specific biosystemThe defensins are a family of antimicrobial cationic peptide molecules which in mammals have a characteristic beta-sheet-rich fold and framework of six disulphide-linked cysteines (Selsted & Ouellet...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipid binding IMP
Inferred from Mutant Phenotype
more info
Process Evidence Code Pubs
NOT defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
NOT defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
Component Evidence Code Pubs
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
extracellular region IEA
Inferred from Electronic Annotation
more info
Preferred Names
beta-defensin 107
beta-defensin 7
defensin, beta 107

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040705.1NP_001035795.1  beta-defensin 107 precursor

    See identical proteins and their annotated locations for NP_001035795.1

    Status: REVIEWED

    Source sequence(s)
    Consensus CDS
    ENSP00000347810.2, OTTHUMP00000195800, ENST00000355602.2, OTTHUMT00000315231
    Conserved Domains (1) summary
    Defensin_beta_2; Beta defensin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly


  1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p7 ALT_REF_LOCI_1


  1. NT_187570.1 Reference GRCh38.p7 ALT_REF_LOCI_1

    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1


  1. NC_018919.2 Alternate CHM1_1.1

    7260964..7274426 complement
    GenBank, FASTA, Sequence Viewer (Graphics)
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