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Zdhhc18 zinc finger, DHHC domain containing 18 [ Mus musculus (house mouse) ]

Gene ID: 503610, updated on 8-Nov-2022

Summary

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Official Symbol
Zdhhc18provided by MGI
Official Full Name
zinc finger, DHHC domain containing 18provided by MGI
Primary source
MGI:MGI:3527792
See related
Ensembl:ENSMUSG00000037553 AllianceGenome:MGI:3527792
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DHHC-18
Summary
Enables palmitoyltransferase activity. Acts upstream of or within cellular protein localization. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC18 (zinc finger DHHC-type palmitoyltransferase 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 53.1), thymus adult (RPKM 41.2) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Zdhhc18 in Genome Data Viewer
Location:
4; 4 D2.3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133331969..133360801, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133604554..133633490, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42324 Neighboring gene stratifin Neighboring gene predicted gene 13213 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class V

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZDHHC18 negatively regulates cGAS-mediated innate immunity through palmitoylation. Shi C, et al. EMBO J, 2022 Jun 1. PMID 35438208,
  2. SAGE2Splice: unmapped SAGE tags reveal novel splice junctions. Kuo BY, et al. PLoS Comput Biol, 2006 Apr. PMID 16683015, Free PMC Article
  3. Identification of PSD-95 palmitoylating enzymes. Fukata M, et al. Neuron, 2004 Dec 16. PMID 15603741
  4. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
  5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

See all (18) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZDHHC18 negatively regulates cGAS-mediated innate immunity through palmitoylation.
    Title: ZDHHC18 negatively regulates cGAS-mediated innate immunity through palmitoylation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC18
Names
DHHC domain-containing cysteine-rich protein 18
zinc finger DHHC domain-containing protein 18
NP_001017968.2
XP_006539081.1
XP_006539083.1
XP_006539084.1
XP_006539085.1
XP_011248601.1
XP_017175794.1
XP_036020116.1
XP_036020117.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017968.2 → NP_001017968.2  palmitoyltransferase ZDHHC18

    See identical proteins and their annotated locations for NP_001017968.2

    Status: VALIDATED

    Source sequence(s)
    AL627228, AY668950, BX537327, CJ049628
    Consensus CDS
    CCDS38906.1
    UniProtKB/Swiss-Prot
    A2A9F0, Q5Y5T2
    Related
    ENSMUSP00000081260.5, ENSMUST00000084238.5
    Conserved Domains (1) summary
    pfam01529
    Location:183 → 306
    zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    133331969..133360801 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320305.3 → XP_017175794.1  palmitoyltransferase ZDHHC18 isoform X3

    Conserved Domains (1) summary
    pfam01529
    Location:183 → 306
    DHHC; DHHC palmitoyltransferase

  2. XM_006539018.2 → XP_006539081.1  palmitoyltransferase ZDHHC18 isoform X1

    Conserved Domains (1) summary
    pfam01529
    Location:183 → 306
    DHHC; DHHC palmitoyltransferase

  3. XM_011250299.3 → XP_011248601.1  palmitoyltransferase ZDHHC18 isoform X5

    See identical proteins and their annotated locations for XP_011248601.1

    Conserved Domains (1) summary
    pfam01529
    Location:183 → 306
    DHHC; DHHC palmitoyltransferase

  4. XM_036164223.1 → XP_036020116.1  palmitoyltransferase ZDHHC18 isoform X2

    Conserved Domains (1) summary
    pfam01529
    Location:183 → 268
    DHHC; DHHC palmitoyltransferase

  5. XM_036164224.1 → XP_036020117.1  palmitoyltransferase ZDHHC18 isoform X6

    Conserved Domains (1) summary
    cl19890
    Location:100 → 265
    DHHC; DHHC palmitoyltransferase

  6. XM_006539022.3 → XP_006539085.1  palmitoyltransferase ZDHHC18 isoform X5

    See identical proteins and their annotated locations for XP_006539085.1

    Conserved Domains (1) summary
    pfam01529
    Location:183 → 306
    DHHC; DHHC palmitoyltransferase

  7. XM_006539021.3 → XP_006539084.1  palmitoyltransferase ZDHHC18 isoform X4

    See identical proteins and their annotated locations for XP_006539084.1

    Conserved Domains (1) summary
    pfam01529
    Location:183 → 306
    DHHC; DHHC palmitoyltransferase

  8. XM_006539020.3 → XP_006539083.1  palmitoyltransferase ZDHHC18 isoform X4

    See identical proteins and their annotated locations for XP_006539083.1

    Conserved Domains (1) summary
    pfam01529
    Location:183 → 306
    DHHC; DHHC palmitoyltransferase

RNA

  1. XR_390767.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5Y5T2.4 GenPept UniProtKB/Swiss-Prot:Q5Y5T2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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