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HNF1B HNF1 homeobox B [ Bos taurus (domestic cattle) ]

Gene ID: 503581, updated on 30-Jan-2025
Official Symbol
HNF1Bprovided by VGNC
Official Full Name
HNF1 homeobox Bprovided by VGNC
Primary source
VGNC:VGNC:29890
See related
BGD:BT20049; EnsemblRapid:ENSBTAG00070029705
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
HNF-1b
Orthologs
human mouse all
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See HNF1B in Genome Data Viewer
Location:
chromosome: 19
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (13973966..14035613, complement)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene synergin gamma Neighboring gene DExD-box helicase 52 Neighboring gene uncharacterized LOC101906072 Neighboring gene uncharacterized LOC104969035 Neighboring gene uncharacterized LOC101906153

Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Growth hormone regulates the expression of hepatocyte nuclear factor-3 gamma and other liver-enriched transcription factors in the bovine liver. Eleswarapu S, et al. J Endocrinol, 2005 Jan. PMID 15642787
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in insulin secretion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in liver development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in pancreas development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
hepatocyte nuclear factor 1-beta
Names
hepatocyte nuclear factor 1 beta

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001192855.1 → NP_001179784.1  hepatocyte nuclear factor 1-beta

    See identical proteins and their annotated locations for NP_001179784.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000019
    UniProtKB/TrEMBL
    F1MK03
    Conserved Domains (3) summary
    cd00086
    Location:232 → 305
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:314 → 550
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
    pfam04814
    Location:8 → 173
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    13973966..14035613 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005219982.5 → XP_005220039.1  hepatocyte nuclear factor 1-beta isoform X3

    See identical proteins and their annotated locations for XP_005220039.1

    Conserved Domains (3) summary
    cd00086
    Location:206 → 279
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:288 → 524
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
    pfam04814
    Location:8 → 173
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

  2. XM_005219981.5 → XP_005220038.1  hepatocyte nuclear factor 1-beta isoform X2

    Conserved Domains (3) summary
    cd00086
    Location:206 → 279
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:288 → 525
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
    pfam04814
    Location:8 → 173
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

  3. XM_005219980.5 → XP_005220037.1  hepatocyte nuclear factor 1-beta isoform X1

    UniProtKB/TrEMBL
    F1MK03
    Related
    ENSBTAP00070041142.1, ENSBTAT00070067380.1
    Conserved Domains (3) summary
    cd00086
    Location:232 → 305
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam04812
    Location:314 → 551
    HNF-1B_C; Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
    pfam04814
    Location:8 → 173
    HNF-1_N; Hepatocyte nuclear factor 1 (HNF-1), N terminus

  4. XM_059877790.1 → XP_059733773.1  hepatocyte nuclear factor 1-beta isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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