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SPRN shadow of prion protein [ Homo sapiens (human) ]

Gene ID: 503542, updated on 26-Oct-2022

Summary

Official Symbol
SPRNprovided by HGNC
Official Full Name
shadow of prion proteinprovided by HGNC
Primary source
HGNC:HGNC:16871
See related
Ensembl:ENSG00000203772 MIM:610447; AllianceGenome:HGNC:16871
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SHO; SHADOO; bA108K14.1
Summary
Predicted to enable nucleic acid binding activity. Predicted to be involved in protein import into nucleus. Predicted to be located in membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 10.6), duodenum (RPKM 4.2) and 25 other tissues See more
Orthologs
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Genomic context

See SPRN in Genome Data Viewer
Location:
10q26.3
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (133420666..133424625, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (134375591..134379547, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135234170..135238129, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902563 Neighboring gene Sharpr-MPRA regulatory region 11835 Neighboring gene polyamine oxidase Neighboring gene mitochondrial ribosome associated GTPase 1 Neighboring gene uncharacterized LOC124902564 Neighboring gene olfactory receptor family 6 subfamily L member 2 pseudogene Neighboring gene scavenger receptor family member expressed on T cells 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41197

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nucleic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
shadow of prion protein
Names
hypothetical protein BC004409
protein shadoo
shadow of prion protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012508.6NP_001012526.2  shadow of prion protein precursor

    See identical proteins and their annotated locations for NP_001012526.2

    Status: VALIDATED

    Source sequence(s)
    AL161645
    Consensus CDS
    CCDS53589.1
    UniProtKB/Swiss-Prot
    Q5BIV9
    Related
    ENSP00000433712.1, ENST00000414069.2
    Conserved Domains (1) summary
    pfam14999
    Location:47138
    Shadoo; Shadow of prion protein, neuroprotective
  2. NM_001391974.1NP_001378903.1  shadow of prion protein precursor

    Status: VALIDATED

    Source sequence(s)
    AL161645
    Consensus CDS
    CCDS53589.1
    UniProtKB/Swiss-Prot
    Q5BIV9
    Related
    ENSP00000510252.1, ENST00000685335.1
    Conserved Domains (1) summary
    pfam14999
    Location:47138
    Shadoo; Shadow of prion protein, neuroprotective

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    133420666..133424625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    134375591..134379547 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)