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P2RY11 purinergic receptor P2Y11 [ Homo sapiens (human) ]

Gene ID: 5032, updated on 28-Jun-2020

Summary

Official Symbol
P2RY11provided by HGNC
Official Full Name
purinergic receptor P2Y11provided by HGNC
Primary source
HGNC:HGNC:8540
See related
Ensembl:ENSG00000244165 MIM:602697
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P2Y11
Summary
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 6.0), lymph node (RPKM 4.7) and 25 other tissues See more
Orthologs

Genomic context

See P2RY11 in Genome Data Viewer
Location:
19p13.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (10111693..10115372)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10222197..10226065)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PPAN-P2RY11 readthrough Neighboring gene Sharpr-MPRA regulatory region 3609 Neighboring gene small nucleolar RNA, C/D box 105 Neighboring gene small nucleolar RNA, C/D box 105B Neighboring gene peter pan homolog Neighboring gene eukaryotic translation initiation factor 3 subunit G Neighboring gene DNA methyltransferase 1 Neighboring gene origin of replication in DNMT1 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough PPAN-P2RY11

Readthrough gene: PPAN-P2RY11, Included gene: PPAN

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP-activated adenosine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP-activated adenosine receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurotransmitter receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IC
Inferred by Curator
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
P2Y purinoceptor 11
Names
purinergic receptor P2Y, G-protein coupled, 11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047007.1 RefSeqGene

    Range
    5173..8852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002566.5NP_002557.2  P2Y purinoceptor 11

    See identical proteins and their annotated locations for NP_002557.2

    Status: REVIEWED

    Source sequence(s)
    BC009877, BC073827
    Consensus CDS
    CCDS12226.1
    UniProtKB/Swiss-Prot
    Q96G91
    Related
    ENSP00000323872.4, ENST00000321826.5
    Conserved Domains (1) summary
    pfam00001
    Location:46321
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    10111693..10115372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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