Angptl3 angiopoietin-like 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Angptl3provided by RGD
Full Name: angiopoietin-like 3provided by RGD
Primary source: RGD:1564505
See related: Ensembl:ENSRNOG00000008638 AllianceGenome:RGD:1564505
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable growth factor activity; integrin binding activity; and phospholipase inhibitor activity. Involved in response to hormone. Predicted to be located in Golgi apparatus; cell surface; and early endosome. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in familial hypobetalipoproteinemia 2. Orthologous to human ANGPTL3 (angiopoietin like 3). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Restricted expression toward (RPKM 1507.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q33

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (118818494..118825531)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (113703007..113710044)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (117698590..117706729)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNA Interference Targeting Liver Angiopoietin-Like Protein 3 Protects from Nephrotic Syndrome in a Rat Model Via Amelioration of Pathologic Hypertriglyceridemia.
Title: RNA Interference Targeting Liver Angiopoietin-Like Protein 3 Protects from Nephrotic Syndrome in a Rat Model Via Amelioration of Pathologic Hypertriglyceridemia.

Submit: New GeneRIF Correction

General gene information

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Markers

RH129449 (e-PCR)
- UniSTS:212755

RH135495 (e-PCR)
- UniSTS:209822

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme inhibitor activity	IEA Inferred from Electronic Annotation more info
enables enzyme inhibitor activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables lipase binding	IEA Inferred from Electronic Annotation more info
enables lipase binding	ISO Inferred from Sequence Orthology more info
enables lipase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables lipase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables phospholipase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables phospholipase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acylglycerol homeostasis	IEA Inferred from Electronic Annotation more info
involved_in acylglycerol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in artery morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in artery morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycerol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid homeostasis	IEA Inferred from Electronic Annotation more info
involved_in lipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid storage	IEA Inferred from Electronic Annotation more info
involved_in lipid storage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of very-low-density lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of very-low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in phospholipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid homeostasis	IEA Inferred from Electronic Annotation more info
involved_in phospholipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of chylomicron remodeling	IEA Inferred from Electronic Annotation more info
involved_in regulation of chylomicron remodeling	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within triglyceride homeostasis	IEA Inferred from Electronic Annotation more info
involved_in triglyceride homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within triglyceride homeostasis	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: angiopoietin-related protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025065.2 → NP_001020236.1 angiopoietin-related protein 3 isoform 2 precursor

See identical proteins and their annotated locations for NP_001020236.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

Q5I0L8

Conserved Domains (1) summary

cl00085
Location:241 → 311

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
NM_001399252.1 → NP_001386181.1 angiopoietin-related protein 3 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A6JRL4, F7FHP0

Related

ENSRNOP00000011486.5, ENSRNOT00000011486.8

Conserved Domains (2) summary

COG1196
Location:90 → 205

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00087
Location:241 → 453

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
NM_001399253.1 → NP_001386182.1 angiopoietin-related protein 3 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A6JRL5

Conserved Domains (1) summary

COG1196
Location:63 → 206

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]