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P2RY2 purinergic receptor P2Y2 [ Homo sapiens (human) ]

Gene ID: 5029, updated on 4-Jun-2020

Summary

Official Symbol
P2RY2provided by HGNC
Official Full Name
purinergic receptor P2Y2provided by HGNC
Primary source
HGNC:HGNC:8541
See related
Ensembl:ENSG00000175591 MIM:600041
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P2U; HP2U; P2U1; P2UR; P2Y2; P2RU1; P2Y2R
Summary
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]
Expression
Broad expression in esophagus (RPKM 5.5), thyroid (RPKM 2.6) and 14 other tissues See more
Orthologs

Genomic context

See P2RY2 in Genome Data Viewer
Location:
11q13.4
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (73200416..73246743)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (72928735..72953472)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369381 Neighboring gene Sharpr-MPRA regulatory region 14106 Neighboring gene uncharacterized LOC105369382 Neighboring gene olfactory receptor family 8 subfamily R member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor.
NHGRI GWA Catalog
Genome-wide association study of body mass index in 23 000 individuals with and without asthma.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37408, MGC20088, MGC40010, DKFZp686H09192

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled purinergic nucleotide receptor activity IEA
Inferred from Electronic Annotation
more info
 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cellular ion homeostasis TAS
Traceable Author Statement
more info
PubMed 
cellular response to ATP TAS
Traceable Author Statement
more info
PubMed 
phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mucus secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of blood vessel diameter IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
P2Y purinoceptor 2
Names
ATP receptor
P2U nucleotide receptor
P2U purinoceptor 1
P2U receptor 1
purinergic receptor P2Y, G-protein coupled, 2
purinoceptor P2Y2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002564.4NP_002555.4  P2Y purinoceptor 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Transcript variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AP002761
    Consensus CDS
    CCDS8219.1
    Related
    ENSP00000377222.2, ENST00000393597.6
  2. NM_176071.3NP_788085.3  P2Y purinoceptor 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Transcript variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AP002761
    Consensus CDS
    CCDS8219.1
    Related
    ENSP00000377221.2, ENST00000393596.2
  3. NM_176072.3NP_788086.3  P2Y purinoceptor 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Transcript variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AP002761
    Consensus CDS
    CCDS8219.1
    Related
    ENSP00000310305.2, ENST00000311131.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    73200416..73246743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017839.1XP_016873328.1  P2Y purinoceptor 2 isoform X1

    UniProtKB/Swiss-Prot
    P41231
    Conserved Domains (1) summary
    pfam00001
    Location:51306
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. XM_005274021.4XP_005274078.1  P2Y purinoceptor 2 isoform X1

    See identical proteins and their annotated locations for XP_005274078.1

    UniProtKB/Swiss-Prot
    P41231
    Conserved Domains (1) summary
    pfam00001
    Location:51306
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. XM_005274019.4XP_005274076.1  P2Y purinoceptor 2 isoform X1

    See identical proteins and their annotated locations for XP_005274076.1

    UniProtKB/Swiss-Prot
    P41231
    Conserved Domains (1) summary
    pfam00001
    Location:51306
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. XM_011545074.2XP_011543376.1  P2Y purinoceptor 2 isoform X1

    See identical proteins and their annotated locations for XP_011543376.1

    UniProtKB/Swiss-Prot
    P41231
    Conserved Domains (1) summary
    pfam00001
    Location:51306
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  5. XM_005274020.4XP_005274077.1  P2Y purinoceptor 2 isoform X1

    See identical proteins and their annotated locations for XP_005274077.1

    UniProtKB/Swiss-Prot
    P41231
    Conserved Domains (1) summary
    pfam00001
    Location:51306
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RNA

  1. XR_001747891.1 RNA Sequence

  2. XR_001747890.1 RNA Sequence

  3. XR_001747892.1 RNA Sequence

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