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P2RY2 purinergic receptor P2Y2 [ Homo sapiens (human) ]

Gene ID: 5029, updated on 8-Jul-2018
Official Symbol
P2RY2provided by HGNC
Official Full Name
purinergic receptor P2Y2provided by HGNC
Primary source
HGNC:HGNC:8541
See related
Ensembl:ENSG00000175591 MIM:600041; Vega:OTTHUMG00000167966
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P2U; HP2U; P2U1; P2UR; P2Y2; P2RU1; P2Y2R
Summary
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]
Expression
Broad expression in esophagus (RPKM 5.5), thyroid (RPKM 2.6) and 14 other tissues See more
Orthologs
See P2RY2 in Genome Data Viewer
Location:
11q13.4
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (73200416..73246743)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (72928735..72953472)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene FCH and double SH3 domains 2 Neighboring gene ribosomal protein L15 pseudogene 16 Neighboring gene uncharacterized LOC105369381 Neighboring gene uncharacterized LOC105369382 Neighboring gene olfactory receptor family 8 subfamily R member 1 pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor.
NHGRI GWA Catalog
Genome-wide association study of body mass index in 23 000 individuals with and without asthma.
NHGRI GWA Catalog
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Nucleotide GPCRs, organism-specific biosystem (from WikiPathways)
    Nucleotide GPCRs, organism-specific biosystem
    Nucleotide GPCRs
  • Nucleotide-like (purinergic) receptors, organism-specific biosystem (from REACTOME)
    Nucleotide-like (purinergic) receptors, organism-specific biosystemPurinergic receptors (Burnstock G, 2006; Abbracchio MP et al, 2009) are a family of newly characterized plasma membrane molecules involved in several cellular functions such as vascular reactivity, a...
  • P2Y receptors, organism-specific biosystem (from REACTOME)
    P2Y receptors, organism-specific biosystemP2Y receptors are a family of purinergic receptors, G protein-coupled receptors stimulated by nucleotides such as ATP, ADP, UTP, UDP and UDP-glucose. To date, 12 P2Y receptors have been cloned in hum...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Surfactant metabolism, organism-specific biosystem (from REACTOME)
    Surfactant metabolism, organism-specific biosystemThe alveolar region of the lung creates an extensive epithelial surface that mediates the transfer of oxygen and carbon dioxide required for respiration after birth. Type I epithelial cells form the ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ37408, MGC20088, MGC40010, DKFZp686H09192

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled purinergic nucleotide receptor activity IEA
Inferred from Electronic Annotation
more info
 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cellular ion homeostasis TAS
Traceable Author Statement
more info
PubMed 
phospholipase C-activating G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mucus secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of blood vessel diameter IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
P2Y purinoceptor 2
Names
ATP receptor
P2U nucleotide receptor
P2U purinoceptor 1
P2U receptor 1
purinergic receptor P2Y, G-protein coupled, 2
purinoceptor P2Y2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002564.3NP_002555.3  P2Y purinoceptor 2

    See identical proteins and their annotated locations for NP_002555.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Transcript variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AP002761, U07225
    Consensus CDS
    CCDS8219.1
    UniProtKB/Swiss-Prot
    P41231
    Related
    ENSP00000377222.2, OTTHUMP00000237494, ENST00000393597.6, OTTHUMT00000397335
    Conserved Domains (1) summary
    cd15373
    Location:34317
    7tmA_P2Y2; P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_176071.2NP_788085.2  P2Y purinoceptor 2

    See identical proteins and their annotated locations for NP_788085.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Transcript variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AP002761, BC028135
    Consensus CDS
    CCDS8219.1
    UniProtKB/Swiss-Prot
    P41231
    Related
    ENSP00000377221.2, OTTHUMP00000237496, ENST00000393596.2, OTTHUMT00000397337
    Conserved Domains (1) summary
    cd15373
    Location:34317
    7tmA_P2Y2; P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_176072.2NP_788086.2  P2Y purinoceptor 2

    See identical proteins and their annotated locations for NP_788086.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Transcript variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AP002761, BC012104
    Consensus CDS
    CCDS8219.1
    UniProtKB/Swiss-Prot
    P41231
    Related
    ENSP00000310305.2, OTTHUMP00000237495, ENST00000311131.6, OTTHUMT00000397336
    Conserved Domains (1) summary
    cd15373
    Location:34317
    7tmA_P2Y2; P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    73200416..73246743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017839.1XP_016873328.1  P2Y purinoceptor 2 isoform X1

    UniProtKB/Swiss-Prot
    P41231
    Conserved Domains (1) summary
    pfam00001
    Location:51306
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. XM_005274021.4XP_005274078.1  P2Y purinoceptor 2 isoform X1

    See identical proteins and their annotated locations for XP_005274078.1

    UniProtKB/Swiss-Prot
    P41231
    Conserved Domains (1) summary
    pfam00001
    Location:51306
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. XM_005274019.4XP_005274076.1  P2Y purinoceptor 2 isoform X1

    See identical proteins and their annotated locations for XP_005274076.1

    UniProtKB/Swiss-Prot
    P41231
    Conserved Domains (1) summary
    pfam00001
    Location:51306
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. XM_011545074.2XP_011543376.1  P2Y purinoceptor 2 isoform X1

    See identical proteins and their annotated locations for XP_011543376.1

    UniProtKB/Swiss-Prot
    P41231
    Conserved Domains (1) summary
    pfam00001
    Location:51306
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  5. XM_005274020.4XP_005274077.1  P2Y purinoceptor 2 isoform X1

    See identical proteins and their annotated locations for XP_005274077.1

    UniProtKB/Swiss-Prot
    P41231
    Conserved Domains (1) summary
    pfam00001
    Location:51306
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RNA

  1. XR_001747891.1 RNA Sequence

  2. XR_001747890.1 RNA Sequence

  3. XR_001747892.1 RNA Sequence

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