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P2RY1 purinergic receptor P2Y1 [ Homo sapiens (human) ]

Gene ID: 5028, updated on 4-Jun-2020

Summary

Official Symbol
P2RY1provided by HGNC
Official Full Name
purinergic receptor P2Y1provided by HGNC
Primary source
HGNC:HGNC:8539
See related
Ensembl:ENSG00000169860 MIM:601167
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P2Y1; SARCC
Summary
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See P2RY1 in Genome Data Viewer
Location:
3q25.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (152835131..152841439)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (152552736..152555845)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724289 Neighboring gene ATP synthase membrane subunit g pseudogene 5 Neighboring gene CRISPRi-validated cis-regulatory element chr3.4520 Neighboring gene Sharpr-MPRA regulatory region 12497

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Interaction of the HIV-1 gp120 with macrophages triggers an increase in ATP release that stimulates purinergic receptor P2X(1), P2X(7), and P2Y(1) proteins and facilitates HIV entry and subsequent stages of viral replication PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
A1 adenosine receptor binding IEA
Inferred from Electronic Annotation
more info
 
ADP binding IEA
Inferred from Electronic Annotation
more info
 
ADP receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ATP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
ATP-activated adenosine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
G protein-coupled purinergic nucleotide receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
scaffold protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenosine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
aging IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cellular response to ATP TAS
Traceable Author Statement
more info
PubMed 
cellular response to purine-containing compound IMP
Inferred from Mutant Phenotype
more info
PubMed 
eating behavior IEA
Inferred from Electronic Annotation
more info
 
glial cell migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of binding IEA
Inferred from Electronic Annotation
more info
 
negative regulation of norepinephrine secretion IEA
Inferred from Electronic Annotation
more info
 
phospholipase C-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
platelet activation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of hormone secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of inositol trisphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ion transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of penile erection IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of blood vessel diameter IEA
Inferred from Electronic Annotation
more info
 
regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of presynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
relaxation of muscle IEA
Inferred from Electronic Annotation
more info
 
response to growth factor IEA
Inferred from Electronic Annotation
more info
 
response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
signal transduction involved in regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface HDA PubMed 
cilium IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of presynaptic active zone membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
P2Y purinoceptor 1
Names
ADP receptor
ATP receptor
P2 purinoceptor subtype Y1
platelet ADP receptor
purinergic receptor P2Y, G-protein coupled, 1
suppressing androgen receptor in renal cell carcinoma

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032896.2 RefSeqGene

    Range
    5185..11493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002563.5NP_002554.1  P2Y purinoceptor 1

    See identical proteins and their annotated locations for NP_002554.1

    Status: REVIEWED

    Source sequence(s)
    AC013251, AK026659, DA396016, DA453416, U42030
    Consensus CDS
    CCDS3169.1
    UniProtKB/Swiss-Prot
    P47900
    Related
    ENSP00000304767.3, ENST00000305097.6
    Conserved Domains (1) summary
    cd15377
    Location:52335
    7tmA_P2Y1; P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    152835131..152841439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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