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P2RX5 purinergic receptor P2X 5 [ Homo sapiens (human) ]

Gene ID: 5026, updated on 13-Apr-2024

Summary

Official Symbol
P2RX5provided by HGNC
Official Full Name
purinergic receptor P2X 5provided by HGNC
Primary source
HGNC:HGNC:8536
See related
Ensembl:ENSG00000083454 MIM:602836; AllianceGenome:HGNC:8536
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P2X5; LRH-1; P2X5R
Summary
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream gene, TAX1BP3 (Tax1 binding protein 3). [provided by RefSeq, Mar 2011]
Expression
Biased expression in lymph node (RPKM 41.6), spleen (RPKM 36.1) and 4 other tissues See more
Orthologs
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Genomic context

See P2RX5 in Genome Data Viewer
Location:
17p13.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (3673227..3696155, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (3562283..3584749, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3576521..3599449, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene P2RX5-TAX1BP3 readthrough (NMD candidate) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3570666-3571197 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:3571198-3571728 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8017 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3572261-3572791 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3572792-3573322 Neighboring gene ribosomal protein L21 pseudogene 125 Neighboring gene Tax1 binding protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3591902-3592810 Neighboring gene ER membrane protein complex subunit 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11513 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3598520-3599036 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8018 Neighboring gene MPRA-validated peak2690 silencer Neighboring gene MPRA-validated peak2691 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:3627127-3627882 Neighboring gene integrin subunit alpha E Neighboring gene Sharpr-MPRA regulatory region 669 Neighboring gene histone H3 associated protein kinase Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:3658435-3659138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11517 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:3697478-3698200 Neighboring gene nonconserved acetylation island sequence 85 enhancer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3701060-3701958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11521 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:3716184-3716689 Neighboring gene nuclear cap binding subunit 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:3735506-3735685 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8020

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of purinergic receptor P2X, ligand-gated ion channel, 5 (P2RX5) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough P2RX5-TAX1BP3

Readthrough gene: P2RX5-TAX1BP3, Included gene: TAX1BP3

Clone Names

  • MGC47755

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chloride transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in osteoclast maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of calcium ion transport into cytosol NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of calcium-mediated signaling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ATP IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
P2X purinoceptor 5
Names
ATP receptor subunit
ionotropic ATP receptor P2X5
lymphoid-restricted histocompatibility antigen-1
purinergic receptor P2X, ligand gated ion channel, 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204519.2NP_001191448.1  P2X purinoceptor 5 isoform D

    See identical proteins and their annotated locations for NP_001191448.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (D) that is shorter than isoform A.
    Source sequence(s)
    AK290889, BC028084
    Consensus CDS
    CCDS56015.1
    UniProtKB/TrEMBL
    K7EQ78
    Related
    ENSP00000448355.1, ENST00000547178.5
    Conserved Domains (1) summary
    TIGR00863
    Location:1350
    P2X; cation transporter protein
  2. NM_001204520.2NP_001191449.1  P2X purinoceptor 5 isoform E

    See identical proteins and their annotated locations for NP_001191449.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (E) that is shorter than isoform A.
    Source sequence(s)
    AA805176, AK290889, DQ234349
    Consensus CDS
    CCDS56014.1
    UniProtKB/TrEMBL
    K7EQ78
    Related
    ENSP00000342161.3, ENST00000345901.7
    Conserved Domains (1) summary
    TIGR00863
    Location:1327
    P2X; cation transporter protein
  3. NM_001425082.1NP_001412011.1  P2X purinoceptor 5 isoform G

    Status: REVIEWED

    Source sequence(s)
    AC116914, AC132942
  4. NM_001425083.1NP_001412012.1  P2X purinoceptor 5 isoform G

    Status: REVIEWED

    Source sequence(s)
    AC116914, AC132942
  5. NM_001425084.1NP_001412013.1  P2X purinoceptor 5 isoform G

    Status: REVIEWED

    Source sequence(s)
    AC116914, AC132942
  6. NM_001425085.1NP_001412014.1  P2X purinoceptor 5 isoform G

    Status: REVIEWED

    Source sequence(s)
    AC116914, AC132942
  7. NM_002561.4NP_002552.2  P2X purinoceptor 5 isoform A

    See identical proteins and their annotated locations for NP_002552.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (A).
    Source sequence(s)
    AA805176, AK290889
    Consensus CDS
    CCDS11034.1
    UniProtKB/Swiss-Prot
    G5E981, O43450, O75540, Q308M5, Q59F38, Q8IXW4, Q93086, Q93087, Q9NZV0
    UniProtKB/TrEMBL
    K7EQ78
    Related
    ENSP00000225328.5, ENST00000225328.10
    Conserved Domains (1) summary
    TIGR00863
    Location:1351
    P2X; cation transporter protein
  8. NM_175080.3NP_778255.1  P2X purinoceptor 5 isoform B

    See identical proteins and their annotated locations for NP_778255.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (B) that is shorter than isoform A.
    Source sequence(s)
    AA805176, AF070573, AK290889
    Consensus CDS
    CCDS11035.1
    UniProtKB/TrEMBL
    K7EQ78
    Related
    ENSP00000447545.1, ENST00000551178.5
    Conserved Domains (1) summary
    TIGR00863
    Location:1326
    P2X; cation transporter protein

RNA

  1. NR_178078.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    CP068261
  2. NR_178079.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    CP068261

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    3673227..3696155 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    3562283..3584749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175081.1: Suppressed sequence

    Description
    NM_175081.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.