U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

P2RX1 purinergic receptor P2X 1 [ Homo sapiens (human) ]

Gene ID: 5023, updated on 22-Sep-2022

Summary

Official Symbol
P2RX1provided by HGNC
Official Full Name
purinergic receptor P2X 1provided by HGNC
Primary source
HGNC:HGNC:8533
See related
Ensembl:ENSG00000108405 MIM:600845; AllianceGenome:HGNC:8533
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P2X1
Summary
The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013]
Expression
Broad expression in bone marrow (RPKM 20.3), urinary bladder (RPKM 20.1) and 15 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See P2RX1 in Genome Data Viewer
Location:
17p13.2
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (3896592..3916465, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (3785217..3805711, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3799886..3819759, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903897 Neighboring gene calcium/calmodulin dependent protein kinase kinase 1 Neighboring gene Sharpr-MPRA regulatory region 11291 Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 Neighboring gene long intergenic non-protein coding RNA 1975

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Infection of CD4+ T cells with HIV-1 in the presence of inhibitors of P2X receptors greatly inhibits HIV-1 infection via both cell-free and cell-to-cell contact in a dose-dependent manner, suggesting P2X receptors interact with gp120/gp41 in viral entry PubMed
env Interaction of the HIV-1 gp120 with macrophages triggers an increase in ATP release that stimulates purinergic receptor P2X(1), P2X(7), and P2Y(1) proteins and facilitates HIV entry and subsequent stages of viral replication PubMed
Envelope transmembrane glycoprotein gp41 env Infection of CD4+ T cells with HIV-1 in the presence of inhibitors of P2X receptors greatly inhibits HIV-1 infection via both cell-free and cell-to-cell contact in a dose-dependent manner, suggesting P2X receptors interact with gp120/gp41 in viral entry PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables extracellularly ATP-gated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables purinergic nucleotide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables suramin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ceramide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
involved_in insemination IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuronal action potential IEA
Inferred from Electronic Annotation
more info
 
involved_in platelet activation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of calcium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of presynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of vascular associated smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in response to ATP IEA
Inferred from Electronic Annotation
more info
 
involved_in serotonin secretion by platelet IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in presynaptic active zone membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
located_in secretory granule membrane TAS
Traceable Author Statement
more info
 
located_in specific granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
P2X purinoceptor 1
Names
ATP receptor
P2X receptor, subunit 1
P2X1 receptor
purinergic receptor P2X, ligand gated ion channel, 1
purinergic receptor P2X1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012109.1 RefSeqGene

    Range
    5202..25075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002558.4NP_002549.1  P2X purinoceptor 1

    See identical proteins and their annotated locations for NP_002549.1

    Status: REVIEWED

    Source sequence(s)
    AC005940, BC044657, BX644575
    Consensus CDS
    CCDS11040.1
    UniProtKB/Swiss-Prot
    P51575, Q9UK84
    Related
    ENSP00000225538.3, ENST00000225538.4
    Conserved Domains (1) summary
    TIGR00863
    Location:1368
    P2X; cation transporter protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    3896592..3916465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721529.3XP_006721592.1  P2X purinoceptor 1 isoform X6

    Conserved Domains (1) summary
    cl02993
    Location:1351
    P2X_receptor; ATP P2X receptor
  2. XM_011523897.3XP_011522199.1  P2X purinoceptor 1 isoform X2

    Conserved Domains (1) summary
    TIGR00863
    Location:1388
    P2X; cation transporter protein
  3. XM_047436159.1XP_047292115.1  P2X purinoceptor 1 isoform X5

  4. XM_011523898.4XP_011522200.1  P2X purinoceptor 1 isoform X3

    Conserved Domains (1) summary
    pfam00864
    Location:59389
    P2X_receptor; ATP P2X receptor
  5. XM_011523899.4XP_011522201.1  P2X purinoceptor 1 isoform X4

    Conserved Domains (1) summary
    pfam00864
    Location:59386
    P2X_receptor; ATP P2X receptor
  6. XM_047436158.1XP_047292114.1  P2X purinoceptor 1 isoform X1

  7. XM_047436161.1XP_047292117.1  P2X purinoceptor 1 isoform X8

  8. XM_011523900.4XP_011522202.1  P2X purinoceptor 1 isoform X7

    Conserved Domains (1) summary
    cl02993
    Location:59187
    P2X_receptor; ATP P2X receptor
  9. XM_047436160.1XP_047292116.1  P2X purinoceptor 1 isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    3785217..3805711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)