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Tmem181 transmembrane protein 181 [ Rattus norvegicus (Norway rat) ]

Gene ID: 502228, updated on 5-Sep-2025
Official Symbol
Tmem181provided by RGD
Official Full Name
transmembrane protein 181provided by RGD
Primary source
RGD:1566403
See related
Ensembl:ENSRNOG00000018158 AllianceGenome:RGD:1566403
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1566403
Summary
Predicted to enable toxic substance binding activity. Predicted to be located in membrane. Orthologous to human TMEM181 (transmembrane protein 181). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Brain (RPKM 170.5), Adrenal (RPKM 88.4) and 9 other tissues See more
Orthologs
human mouse all
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See Tmem181 in Genome Data Viewer
Location:
1q11
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (49235923..49290244)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (46830812..46885173)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (47162394..47202554)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551377 Neighboring gene TUB like protein 4 Neighboring gene transfer RNA proline (anticodon AGG) 33 Neighboring gene uncharacterized LOC134482652 Neighboring gene dynein light chain Tctex-type 1 Neighboring gene synaptotagmin-like 3 Neighboring gene uncharacterized LOC120099117

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Haploid genetic screens in human cells identify host factors used by pathogens. Carette JE, et al. Science, 2009 Nov 27. PMID 19965467
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables toxic substance binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables toxic substance binding IEA
Inferred from Electronic Annotation
more info
  
enables toxic substance binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
transmembrane protein 181

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130939.1 → NP_001124411.1  transmembrane protein 181

    See identical proteins and their annotated locations for NP_001124411.1

    Status: PROVISIONAL

    Source sequence(s)
    BC168231
    UniProtKB/TrEMBL
    A0A8I6GKL8, B4F7D5
    Related
    ENSRNOP00000059824.1, ENSRNOT00000068457.4
    Conserved Domains (1) summary
    pfam06664
    Location:128 → 423
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    49235923..49290244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088223.2 → XP_038944151.1  transmembrane protein 181 isoform X2

    Conserved Domains (1) summary
    pfam06664
    Location:169 → 410
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

  2. XM_039088219.2 → XP_038944147.1  transmembrane protein 181 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GD86, A0A8I6GKL8
    Related
    ENSRNOP00000102101.1, ENSRNOT00000161806.1
    Conserved Domains (1) summary
    pfam06664
    Location:169 → 464
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion
Nucleotide Protein Strain
Heading Accession and Version

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