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OXT oxytocin/neurophysin I prepropeptide [ Homo sapiens (human) ]

Gene ID: 5020, updated on 13-Mar-2020

Summary

Official Symbol
OXTprovided by HGNC
Official Full Name
oxytocin/neurophysin I prepropeptideprovided by HGNC
Primary source
HGNC:HGNC:8528
See related
Ensembl:ENSG00000101405 MIM:167050
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OT; OT-NPI; OXT-NPI
Summary
This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013]
Expression
Biased expression in liver (RPKM 1.6), kidney (RPKM 0.7) and 5 other tissues See more
Orthologs

Genomic context

See OXT in Genome Data Viewer
Location:
20p13
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (3068871..3072517)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3052266..3053163)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene gonadotropin releasing hormone 2 Neighboring gene mitochondrial ribosomal protein S26 Neighboring gene uncharacterized LOC101929098 Neighboring gene CRISPRi-validated cis-regulatory element chr20.213 Neighboring gene arginine vasopressin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126890, MGC126892

Gene Ontology Provided by GOA

Function Evidence Code Pubs
neurohypophyseal hormone activity IEA
Inferred from Electronic Annotation
more info
 
neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxytocin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
drinking behavior IEA
Inferred from Electronic Annotation
more info
 
eating behavior IEA
Inferred from Electronic Annotation
more info
 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
grooming behavior IEA
Inferred from Electronic Annotation
more info
 
heart development IEA
Inferred from Electronic Annotation
more info
 
hyperosmotic salinity response IEA
Inferred from Electronic Annotation
more info
 
male mating behavior IEA
Inferred from Electronic Annotation
more info
 
maternal aggressive behavior IEA
Inferred from Electronic Annotation
more info
 
maternal behavior IEA
Inferred from Electronic Annotation
more info
 
memory IEA
Inferred from Electronic Annotation
more info
 
negative regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gastric acid secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of urine volume IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of female receptivity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hindgut contraction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of norepinephrine secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ossification IEA
Inferred from Electronic Annotation
more info
 
positive regulation of penile erection IEA
Inferred from Electronic Annotation
more info
 
positive regulation of prostaglandin secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of renal sodium excretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
positive regulation of uterine smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
regulation of heart rate IEA
Inferred from Electronic Annotation
more info
 
regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
response to activity IEA
Inferred from Electronic Annotation
more info
 
response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
response to cAMP IEA
Inferred from Electronic Annotation
more info
 
response to cocaine IEA
Inferred from Electronic Annotation
more info
 
response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to ether IEA
Inferred from Electronic Annotation
more info
 
response to food IEA
Inferred from Electronic Annotation
more info
 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 
response to progesterone IEA
Inferred from Electronic Annotation
more info
 
response to prostaglandin E IEA
Inferred from Electronic Annotation
more info
 
response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
response to sucrose IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
sleep IEA
Inferred from Electronic Annotation
more info
 
social behavior IEA
Inferred from Electronic Annotation
more info
 
sperm ejaculation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
terminal bouton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
oxytocin-neurophysin 1
Names
neurophysin I
oxytocin, prepro- (neurophysin I)
oxytocin, prepropeptide
oxytocin-neurophysin I, preproprotein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000915.4NP_000906.1  oxytocin-neurophysin 1 preproprotein

    See identical proteins and their annotated locations for NP_000906.1

    Status: REVIEWED

    Source sequence(s)
    AI185553, BC069144
    Consensus CDS
    CCDS13044.1
    UniProtKB/Swiss-Prot
    P01178
    UniProtKB/TrEMBL
    X5D7M6
    Related
    ENSP00000217386.2, ENST00000217386.2
    Conserved Domains (1) summary
    pfam00184
    Location:39116
    Hormone_5; Neurohypophysial hormones, C-terminal Domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    3068871..3072517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529238.1XP_011527540.1  oxytocin-neurophysin 1 isoform X1

    See identical proteins and their annotated locations for XP_011527540.1

    UniProtKB/Swiss-Prot
    P01178
    UniProtKB/TrEMBL
    X5D7M6
    Conserved Domains (1) summary
    pfam00184
    Location:39116
    Hormone_5; Neurohypophysial hormones, C-terminal Domain
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