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OVGP1 oviductal glycoprotein 1 [ Homo sapiens (human) ]

Gene ID: 5016, updated on 5-Sep-2021

Summary

Official Symbol
OVGP1provided by HGNC
Official Full Name
oviductal glycoprotein 1provided by HGNC
Primary source
HGNC:HGNC:8524
See related
Ensembl:ENSG00000085465 MIM:603578
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EGP; OGP; MUC9; CHIT5
Summary
This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]
Expression
Broad expression in endometrium (RPKM 11.4), testis (RPKM 3.0) and 16 other tissues See more
Orthologs
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Genomic context

See OVGP1 in Genome Data Viewer
Location:
1p13.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (111414319..111427735, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (111956941..111970357, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 12 Neighboring gene pepsinogen B, pseudogene Neighboring gene UBE2F pseudogene 3 Neighboring gene WD repeat domain 77

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: WDR77

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chitin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in chitin catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in female pregnancy TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of binding of sperm to zona pellucida IEA
Inferred from Electronic Annotation
more info
 
involved_in single fertilization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in egg coat IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in perivitelline space IEA
Inferred from Electronic Annotation
more info
 
located_in transport vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
oviduct-specific glycoprotein
Names
estrogen-dependent oviduct protein
mucin 9
oviduct glycoprotein
oviductal glycoprotein 1, 120kDa
oviductin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052675.1 RefSeqGene

    Range
    5043..18459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002557.4NP_002548.3  oviduct-specific glycoprotein precursor

    See identical proteins and their annotated locations for NP_002548.3

    Status: REVIEWED

    Source sequence(s)
    AY189737, U09550
    Consensus CDS
    CCDS834.1
    UniProtKB/Swiss-Prot
    Q12889
    UniProtKB/TrEMBL
    Q86YN0
    Related
    ENSP00000358747.3, ENST00000369732.4
    Conserved Domains (2) summary
    cd02872
    Location:24382
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    COG3889
    Location:368557
    COG3889; Predicted periplasmic protein [Function unknown]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    111414319..111427735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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