Tasl TLR adaptor interacting with endolysosomal SLC15A4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Taslprovided by RGD
Official Full Name: TLR adaptor interacting with endolysosomal SLC15A4provided by RGD
Primary source: RGD:1565785
See related: Ensembl:ENSRNOG00000003748 AllianceGenome:RGD:1565785
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565785
Summary: Predicted to be involved in positive regulation of toll-like receptor 7 signaling pathway; positive regulation of toll-like receptor 8 signaling pathway; and regulation of lysosomal lumen pH. Predicted to be located in cytosol; endolysosome membrane; and nucleoplasm. Orthologous to human TASL (TLR adaptor interacting with endolysosomal SLC15A4). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Spleen (RPKM 80.3), Thymus (RPKM 29.8) and 6 other tissues See more
Orthologs: all
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Genomic context

Location:: Xq21

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (54354755..54373930)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (50403962..50423141)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in positive regulation of innate immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 7 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of toll-like receptor 7 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 8 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of toll-like receptor 8 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 9 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of toll-like receptor 9 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endolysosome membrane	IEA Inferred from Electronic Annotation more info
located_in endolysosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TLR adapter interacting with SLC15A4 on the lysosome

Names: uncharacterized protein CXorf21 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109318.1 → NP_001102788.1 TLR adapter interacting with SLC15A4 on the lysosome

Status: PROVISIONAL

Source sequence(s)

CH473966

UniProtKB/TrEMBL

D3ZRK2

Related

ENSRNOP00000004977.3, ENSRNOT00000004977.6

Conserved Domains (1) summary

pfam15133
Location:1 → 293

DUF4569; Domain of unknown function (DUF4569)