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Tafa5 TAFA chemokine like family member 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500915, updated on 23-Jul-2026
Official Symbol
Tafa5provided by RGD
Official Full Name
TAFA chemokine like family member 5provided by RGD
Primary source
RGD:1562115
See related
Ensembl:ENSRNOG00000049349 AllianceGenome:RGD:1562115
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tafa-5; Fam19a5; RGD1562115
Summary
Enables receptor ligand activity. Acts upstream of or within several processes, including negative regulation of vascular associated smooth muscle cell migration; negative regulation of vascular associated smooth muscle cell proliferation; and negative regulation of vascular wound healing. Located in extracellular space. Orthologous to human TAFA5 (TAFA chemokine like family member 5). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Brain (RPKM 158.8), Testes (RPKM 17.8) and 3 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Tafa5 in Genome Data Viewer
Location:
7q34
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (120493447..120714720)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (118613731..118835016)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene nucleosome assembly protein 1 like 6 Neighboring gene uncharacterized LOC108351522 Neighboring gene basic proline-rich protein-like Neighboring gene uncharacterized LOC102546882

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The putative neuropeptide TAFA5 is expressed in the hypothalamic paraventricular nucleus and is regulated by dehydration. Paulsen SJ, et al. Brain Res, 2008 Mar 14. PMID 18275939
  2. Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2. Wang Y, et al. Circulation, 2018 Jul 3. PMID 29453251
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel adipokine, FAM19A5, was capable of inhibiting postinjury neointima formation via sphingosine-1-phosphate receptor 2-G12/13-RhoA signaling.
    Title: Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2.
  2. we found TAFA5 mRNA to be highly expressed in the hypothalamic paraventricular nucleus (PVN) where it co-localized with vasopressin and oxytocin in magno- and parvocellular neurons.
    Title: The putative neuropeptide TAFA5 is expressed in the hypothalamic paraventricular nucleus and is regulated by dehydration.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables receptor ligand activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of vascular wound healing IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of vascular wound healing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
chemokine-like protein TAFA-5
Names
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
family with sequence similarity 19 member A5, C-C motif chemokine like
protein FAM19A5

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191991.1 → NP_001178920.1  chemokine-like protein TAFA-5 precursor

    See identical proteins and their annotated locations for NP_001178920.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    M0R7X9
    Conserved Domains (1) summary
    pfam12020
    Location:42 → 131
    TAFA; TAFA family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    120493447..120714720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079768.2 → XP_038935696.1  chemokine-like protein TAFA-5 isoform X3

    UniProtKB/TrEMBL
    A0ACJ1M2L4
    Related
    ENSRNOP00000065567.2, ENSRNOT00000074625.4
    Conserved Domains (1) summary
    pfam12020
    Location:42 → 92
    TAFA; TAFA family

  2. XM_017595060.3 → XP_017450549.1  chemokine-like protein TAFA-5 isoform X2

    UniProtKB/TrEMBL
    A0ABK0LIE4
    Related
    ENSRNOP00000102712.1, ENSRNOT00000135490.1
    Conserved Domains (1) summary
    pfam12020
    Location:35 → 124
    TAFA; TAFA family

  3. XM_039079767.2 → XP_038935695.1  chemokine-like protein TAFA-5 isoform X1

    Conserved Domains (1) summary
    pfam12020
    Location:35 → 85
    TAFA; TAFA family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M0R7X9.1 GenPept UniProtKB/Swiss-Prot:M0R7X9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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