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Ncf4 neutrophil cytosolic factor 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500904, updated on 18-Apr-2019

Summary

Official Symbol
Ncf4provided by RGD
Official Full Name
neutrophil cytosolic factor 4provided by RGD
Primary source
RGD:1593157
See related
Ensembl:ENSRNOG00000006940
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Spleen (RPKM 99.4), Lung (RPKM 35.6) and 7 other tissues See more
Orthologs

Genomic context

See Ncf4 in Genome Data Viewer
Location:
7q34
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (119481711..119499426)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (119473732..119490872)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 27 Neighboring gene parvalbumin Neighboring gene colony stimulating factor 2 receptor beta common subunit Neighboring gene testis expressed 33

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-3-phosphate binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
PubMed 
superoxide-generating NADPH oxidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
superoxide-generating NADPH oxidase activator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
phagocytosis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
respiratory burst IEA
Inferred from Electronic Annotation
more info
 
superoxide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
NADPH oxidase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NADPH oxidase complex ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
endosome membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
neutrophil cytosol factor 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127304.1NP_001120776.1  neutrophil cytosol factor 4

    See identical proteins and their annotated locations for NP_001120776.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473950
    UniProtKB/TrEMBL
    B2RZ98
    Related
    ENSRNOP00000009544.6, ENSRNOT00000009544.6
    Conserved Domains (3) summary
    cd06399
    Location:238329
    PB1_P40; The PB1 domain is essential part of the p40 adaptor protein which plays an important role in activating phagocyte NADPH oxidase during phagocytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in ...
    cd06882
    Location:19141
    PX_p40phox; The phosphoinositide binding Phox Homology domain of the p40phox subunit of NADPH oxidase
    cd11869
    Location:174227
    SH3_p40phox; Src Homology 3 domain of the p40phox subunit of NADPH oxidase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

    Range
    119481711..119499426
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241939.3XP_006242001.1  neutrophil cytosol factor 4 isoform X1

    Conserved Domains (3) summary
    cd06399
    Location:254345
    PB1_P40; The PB1 domain is essential part of the p40 adaptor protein which plays an important role in activating phagocyte NADPH oxidase during phagocytosis. The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in ...
    cd06882
    Location:56157
    PX_p40phox; The phosphoinositide binding Phox Homology domain of the p40phox subunit of NADPH oxidase
    cd11869
    Location:190243
    SH3_p40phox; Src Homology 3 domain of the p40phox subunit of NADPH oxidase

Alternate Rn_Celera

Genomic

  1. AC_000075.1 Alternate Rn_Celera

    Range
    106165444..106181739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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