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Sybu syntabulin [ Rattus norvegicus (Norway rat) ]

Gene ID: 500865, updated on 6-Jun-2024

Summary

Official Symbol
Sybuprovided by RGD
Official Full Name
syntabulinprovided by RGD
Primary source
RGD:1564335
See related
Ensembl:ENSRNOG00000004200 AllianceGenome:RGD:1564335
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ocsyn; Golsyn; RGD1564335
Summary
Enables microtubule binding activity. Involved in several processes, including axonal transport; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and regulation of synaptic activity. Acts upstream of or within regulation of insulin secretion involved in cellular response to glucose stimulus. Located in dense body; microtubule; and vesicle. Orthologous to human SYBU (syntabulin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 141.5), Heart (RPKM 14.6) and 3 other tissues See more
Orthologs
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Genomic context

See Sybu in Genome Data Viewer
Location:
7q31
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (77731662..77833413, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (75847000..75948919, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (83600614..83670121, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene PKHD1 like 1 Neighboring gene estrogen receptor binding site associated antigen 9 Neighboring gene uncharacterized LOC134479721 Neighboring gene Smg5 nonsense mediated mRNA decay factor like 1 Neighboring gene U2 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA48

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dense body IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
syntabulin
Names
Golgi-localized protein
syntabulin (syntaxin-interacting)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427665.1NP_001414594.1  syntabulin

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I5ZLI6, A6HRC1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    77731662..77833413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264119.1XP_063120189.1  syntabulin isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZLI6, F1LUC0
  2. XM_039080175.2XP_038936103.1  syntabulin isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZLI6, A6HRC1
    Related
    ENSRNOP00000085889.1
    Conserved Domains (1) summary
    pfam15290
    Location:215510
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  3. XM_063264118.1XP_063120188.1  syntabulin isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZLI6
  4. XM_063264115.1XP_063120185.1  syntabulin isoform X1

    UniProtKB/TrEMBL
    A0A8I6A508, A0A8I6AS68
  5. XM_039080176.1XP_038936104.1  syntabulin isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZLI6, F1LUC0
    Related
    ENSRNOP00000005584.7, ENSRNOT00000005584.9
    Conserved Domains (1) summary
    pfam15290
    Location:214509
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  6. XM_006241616.3XP_006241678.1  syntabulin isoform X4

    See identical proteins and their annotated locations for XP_006241678.1

    UniProtKB/TrEMBL
    A0A8I5ZLI6, A6HRC1
    Conserved Domains (1) summary
    pfam15290
    Location:215510
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  7. XM_063264116.1XP_063120186.1  syntabulin isoform X2

    UniProtKB/TrEMBL
    A0A8I6A508
  8. XM_063264117.1XP_063120187.1  syntabulin isoform X3

    UniProtKB/TrEMBL
    A0A8I6A508
  9. XM_006241617.4XP_006241679.1  syntabulin isoform X5

    See identical proteins and their annotated locations for XP_006241679.1

    UniProtKB/TrEMBL
    A0A8I5ZLI6
    Conserved Domains (1) summary
    pfam15290
    Location:238428
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  10. XM_039080181.2XP_038936109.1  syntabulin isoform X9

    Conserved Domains (1) summary
    pfam15290
    Location:5300
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  11. XM_039080180.2XP_038936108.1  syntabulin isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZLI6
    Conserved Domains (1) summary
    pfam15290
    Location:77372
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  12. XM_039080178.2XP_038936106.1  syntabulin isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZLI6
    Conserved Domains (1) summary
    pfam15290
    Location:78373
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  13. XM_039080183.2XP_038936111.1  syntabulin isoform X9

    Conserved Domains (1) summary
    pfam15290
    Location:5300
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
  14. XM_039080182.2XP_038936110.1  syntabulin isoform X9

    Conserved Domains (1) summary
    pfam15290
    Location:5300
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp