Il22 interleukin 22 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il22provided by RGD
Official Full Name: interleukin 22provided by RGD
Primary source: RGD:1561292
See related: Ensembl:ENSRNOG00000007365 AllianceGenome:RGD:1561292
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: If2b1; RGD1561292
Summary: Predicted to enable cytokine activity. Involved in response to glucocorticoid. Located in extracellular space. Used to study asthma and myocarditis. Orthologous to human IL22 (interleukin 22). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Restricted expression toward (RPKM 17.3) See more
Orthologs: human all
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Genomic context

Location:: 7q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (55687061..55691526)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (53801206..53805673)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (61236037..61240502)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results suggest that the transplantation of mesenchymal stem cells can reduce the expression of RANKL in vivo by downregulating the levels of IL-22, thereby ameliorating the degree of rheumatoid arthritis.
Title: Bone Marrow Mesenchymal Stem Cells Decrease the Expression of RANKL in Collagen-Induced Arthritis Rats via Reducing the Levels of IL-22.
IL22 may serve an important role in the pathological process of pristaneinduced arthritis, particularly in the chronic fluctuation phase.
Title: IL‑22 expression is increased variedly in the initial phase, onset and chronic phase of a pristane‑induced arthritis rat model.
conclude that IL-22 expression level was increased and correlated with disease severity, which indicated that IL-22 may play an important role in development of PIA, and was helpful to explorer the pathogenesis of rheumatoid arthritis
Title: Increased expression of Th17 cytokines and interleukin-22 correlates with disease activity in pristane-induced arthritis in rats.
The that IL-22 plays a protective role in this process via the down-regulation of uncoupling protein-2 (UCP-2).
Title: Interleukin-22 restored mitochondrial damage and impaired glucose-stimulated insulin secretion through down-regulation of uncoupling protein-2 in INS-1 cells.
IL-22 might influence SCchwann cell proliferation and apoptosis.
Title: IL-22 Impedes the Proliferation of Schwann cells: Transcriptome Sequencing and Bioinformatics Analysis.
IL-22BP is produced by eosinophils in the gut and blocks IL-22 protective actions in colitis.
Title: IL-22BP is produced by eosinophils in human gut and blocks IL-22 protective actions during colitis.
In skin from diabetic rats, IL-22 mRNA expression 1 day after wounding was 53.5 +/- 3.7% of that seen in control rats
Title: High-glucose-cultivated peripheral blood mononuclear cells impaired keratinocyte function via reduced IL-22 expression: implications on impaired diabetic wound healing.
this is the first report showing that IL-22 confers a neuroprotective function
Title: Interleukin-22 protects rat PC12 pheochromocytoma cells from serum deprivation-induced cell death.
high IL22 levels during the induction and peak phases that markedly decrease during recovery phase of experimental autoimmune encephalomyelitis
Title: Increase in Th17 and T-reg lymphocytes and decrease of IL22 correlate with the recovery phase of acute EAE in rat.
IL-22, likely via activation of STAT3 and downstream genes (e.g., SOCS3), is able to protect against cell stretch and pulmonary baro-/biotrauma by enhancing epithelial cell resistibility
Title: Protective properties of inhaled IL-22 in a model of ventilator-induced lung injury.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-22

Names: interferon 2b1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.