Sptssa serine palmitoyltransferase, small subunit A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sptssaprovided by RGD
Official Full Name: serine palmitoyltransferase, small subunit Aprovided by RGD
Primary source: RGD:1565821
See related: Ensembl:ENSRNOG00000004292 AllianceGenome:RGD:1565821
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ssspta
Summary: Predicted to contribute to serine C-palmitoyltransferase activity. Predicted to be involved in ceramide biosynthetic process and protein localization. Predicted to be located in endoplasmic reticulum. Predicted to be part of serine C-palmitoyltransferase complex. Orthologous to human SPTSSA (serine palmitoyltransferase small subunit A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 650.9), Liver (RPKM 356.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q23

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
108	current	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (72144714..72156130, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (75540132..75551545, complement)

Chromosome 6 - NC_051341.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Homology

Homologs of the Sptssa gene: The Sptssa gene is conserved in human, chimpanzee, Rhesus monkey, cow, mouse, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 454 organisms have orthologs with human gene Sptssa
Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to serine C-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
contributes_to serine C-palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
enables serine C-palmitoyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to serine C-palmitoyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ceramide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within ceramide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in sphingosine biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
part_of serine C-palmitoyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of serine C-palmitoyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of serine C-palmitoyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine palmitoyltransferase small subunit A

Names: small subunit of serine palmitoyltransferase A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.