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Pcbp1 poly(rC) binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500242, updated on 8-Apr-2026
Official Symbol
Pcbp1provided by RGD
Official Full Name
poly(rC) binding protein 1provided by RGD
Primary source
RGD:1561319
See related
Ensembl:ENSRNOG00000017708 AllianceGenome:RGD:1561319
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561319
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; mRNA binding activity; and sequence-specific single stranded DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and viral RNA genome replication. Is active in postsynaptic density. Orthologous to human PCBP1 (poly(rC) binding protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See Pcbp1 in Genome Data Viewer
Location:
4q34
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (120530100..120532107, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (118972698..118974705, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (118327185..118329223, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 2 open reading frame 42 Neighboring gene uncharacterized LOC134486603 Neighboring gene uncharacterized LOC134486604 Neighboring gene translation machinery associated 7 homolog like 1 Neighboring gene uncharacterized LOC102554372

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing. Wen W, et al. Cell Discov, 2020. PMID 32377375, Free PMC Article
  2. Conserved role for PCBP1 in altered RNA splicing in the hippocampus after chronic alcohol exposure. Carvalho L, et al. Mol Psychiatry, 2023 Oct. PMID 37537282, Free PMC Article
  3. Poly C binding protein, a single-stranded DNA binding protein, regulates mouse mu-opioid receptor gene expression. Ko JL, et al. J Neurochem, 2005 May. PMID 15836633
  4. Molecular basis of cellular localization of poly C binding protein 1 in neuronal cells. Berry AM, et al. Biochem Biophys Res Commun, 2006 Nov 3. PMID 16979592, Free PMC Article
  5. Identification of two KH domain proteins in the alpha-globin mRNP stability complex. Kiledjian M, et al. EMBO J, 1995 Sep 1. PMID 7556077, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Conserved role for PCBP1 in altered RNA splicing in the hippocampus after chronic alcohol exposure.
    Title: Conserved role for PCBP1 in altered RNA splicing in the hippocampus after chronic alcohol exposure.
  2. These results are consistent with a model where hnRNP E1 recruited to A2RE RNA granules by binding to hnRNP A2 inhibits translation of A2RE RNA during granule transport.
    Title: Heterogeneous nuclear ribonucleoprotein (hnRNP) E1 binds to hnRNP A2 and inhibits translation of A2 response element mRNAs.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific single stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific single stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in viral RNA genome replication IEA
Inferred from Electronic Annotation
more info
  
involved_in viral RNA genome replication ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density EXP
Inferred from Experiment
more info
 PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
poly(rC)-binding protein 1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399658.1 → NP_001386587.1  poly(rC)-binding protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6AH91, A6IAY0
    Related
    ENSRNOP00000092121.1, ENSRNOT00000023806.5
    Conserved Domains (3) summary
    cd22515
    Location:13 → 82
    KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22518
    Location:92 → 169
    KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
    cd22521
    Location:276 → 351
    KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    120530100..120532107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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Chemical Information
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Research Materials
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