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Cep41 centrosomal protein 41 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500069, updated on 5-Jan-2022

Summary

Official Symbol
Cep41provided by RGD
Official Full Name
centrosomal protein 41provided by RGD
Primary source
RGD:1562034
See related
Ensembl:ENSRNOG00000010950
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tsga14
Summary
Predicted to be involved in cilium assembly and protein polyglutamylation. Predicted to be located in centriole; centrosome; and ciliary basal body. Human ortholog(s) of this gene implicated in Joubert syndrome 15. Orthologous to human CEP41 (centrosomal protein 41). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Testes (RPKM 44.0), Thymus (RPKM 35.2) and 9 other tissues See more
Orthologs
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Genomic context

See Cep41 in Genome Data Viewer
Location:
4q22
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (59271218..59312343, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (57966783..58006931, complement)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene carboxypeptidase A5 Neighboring gene carboxypeptidase A1 Neighboring gene uncharacterized LOC120102252 Neighboring gene mesoderm specific transcript Neighboring gene COPI coat complex subunit gamma 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC112886

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein polyglutamylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in centriole IEA
Inferred from Electronic Annotation
more info
 
located_in centriole ISO
Inferred from Sequence Orthology
more info
 
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary basal body IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cilium ISO
Inferred from Sequence Orthology
more info
 
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
centrosomal protein of 41 kDa
Names
centrosomal protein 41kDa
testis specific gene A14
testis specific, 14
testis-specific gene A14 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025770.2NP_001020941.1  centrosomal protein of 41 kDa

    See identical proteins and their annotated locations for NP_001020941.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098832
    UniProtKB/Swiss-Prot
    Q4KM37
    Related
    ENSRNOP00000014621.4, ENSRNOT00000014621.7
    Conserved Domains (1) summary
    cd00158
    Location:136221
    RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    59271218..59312343 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108120.1XP_038964048.1  centrosomal protein of 41 kDa isoform X2

    Conserved Domains (1) summary
    pfam00581
    Location:135220
    Rhodanese; Rhodanese-like domain
  2. XM_006236229.4XP_006236291.1  centrosomal protein of 41 kDa isoform X1

    See identical proteins and their annotated locations for XP_006236291.1

    UniProtKB/TrEMBL
    A0A096MJP4
    Related
    ENSRNOP00000068210.1, ENSRNOT00000076645.3
    Conserved Domains (1) summary
    cd00158
    Location:170255
    RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
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